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Page 1
Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Posner GH, et al. Among authors: cumming jn. Bioorg Med Chem. 1997 Jul;5(7):1257-65. doi: 10.1016/s0968-0896(97)00079-5. Bioorg Med Chem. 1997. PMID: 9377085 Free article.
Antimalarial cyclic peroxy ketals.
Posner GH, O'Dowd H, Ploypradith P, Cumming JN, Xie S, Shapiro TA. Posner GH, et al. Among authors: cumming jn. J Med Chem. 1998 Jun 4;41(12):2164-7. doi: 10.1021/jm980088f. J Med Chem. 1998. PMID: 9622557
Synthesis and in vitro antimalarial activity of sulfone endoperoxides.
Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Bachi MD, et al. Among authors: cumming jn. Bioorg Med Chem Lett. 1998 Apr 21;8(8):903-8. doi: 10.1016/s0960-894x(98)00141-3. Bioorg Med Chem Lett. 1998. PMID: 9871509 Free article.
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
Mandal M, Zhu Z, Cumming JN, Liu X, Strickland C, Mazzola RD, Caldwell JP, Leach P, Grzelak M, Hyde L, Zhang Q, Terracina G, Zhang L, Chen X, Kuvelkar R, Kennedy ME, Favreau L, Cox K, Orth P, Buevich A, Voigt J, Wang H, Kazakevich I, McKittrick BA, Greenlee W, Parker EM, Stamford AW. Mandal M, et al. Among authors: cumming jn. J Med Chem. 2012 Nov 8;55(21):9331-45. doi: 10.1021/jm301039c. Epub 2012 Oct 1. J Med Chem. 2012. PMID: 22989333
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J. Iserloh U, et al. Among authors: cumming jn. Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. doi: 10.1016/j.bmcl.2007.10.116. Epub 2007 Nov 6. Bioorg Med Chem Lett. 2008. PMID: 18023580
31 results