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Engineering disulfide-linked single-chain Fv dimers [(sFv')2] with improved solution and targeting properties: anti-digoxin 26-10 (sFv')2 and anti-c-erbB-2 741F8 (sFv')2 made by protein folding and bonded through C-terminal cysteinyl peptides.
McCartney JE, Tai MS, Hudziak RM, Adams GP, Weiner LM, Jin D, Stafford WF 3rd, Liu S, Bookman MA, Laminet AA, et al. McCartney JE, et al. Protein Eng. 1995 Mar;8(3):301-14. doi: 10.1093/protein/8.3.301. Protein Eng. 1995. PMID: 7479692
Optimization of in vivo tumor targeting in SCID mice with divalent forms of 741F8 anti-c-erbB-2 single-chain Fv: effects of dose escalation and repeated i.v. administration.
Adams GP, McCartney JE, Wolf EJ, Eisenberg J, Tai MS, Huston JS, Stafford WF 3rd, Bookman MA, Houston LL, Weiner LM. Adams GP, et al. Among authors: mccartney je. Cancer Immunol Immunother. 1995 May;40(5):299-306. doi: 10.1007/BF01519629. Cancer Immunol Immunother. 1995. PMID: 7600561 Free PMC article.
Radiometal labeling of recombinant proteins by a genetically engineered minimal chelation site: technetium-99m coordination by single-chain Fv antibody fusion proteins through a C-terminal cysteinyl peptide.
George AJ, Jamar F, Tai MS, Heelan BT, Adams GP, McCartney JE, Houston LL, Weiner LM, Oppermann H, Peters AM. George AJ, et al. Among authors: mccartney je. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8358-62. doi: 10.1073/pnas.92.18.8358. Proc Natl Acad Sci U S A. 1995. PMID: 7667295 Free PMC article.
38 results