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Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R. Petitclerc E, et al. Among authors: mounetou e. Cancer Res. 2004 Jul 1;64(13):4654-63. doi: 10.1158/0008-5472.CAN-03-3715. Cancer Res. 2004. PMID: 15231678
Alkylation of beta-tubulin on Glu 198 by a microtubule disrupter.
Bouchon B, Chambon C, Mounetou E, Papon J, Miot-Noirault E, Gaudreault RC, Madelmont JC, Degoul F. Bouchon B, et al. Among authors: mounetou e. Mol Pharmacol. 2005 Nov;68(5):1415-22. doi: 10.1124/mol.105.015586. Epub 2005 Aug 12. Mol Pharmacol. 2005. PMID: 16099845
N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice.
Borel M, Degoul F, Communal Y, Mounetou E, Bouchon B, C-Gaudreault R, Madelmont JC, Miot-Noirault E. Borel M, et al. Among authors: mounetou e. Br J Cancer. 2007 Jun 4;96(11):1684-91. doi: 10.1038/sj.bjc.6603778. Epub 2007 May 8. Br J Cancer. 2007. PMID: 17486131 Free PMC article.
26 results