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Page 1
Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.
Sall DJ, Bastian JA, Briggs SL, Buben JA, Chirgadze NY, Clawson DK, Denney ML, Giera DD, Gifford-Moore DS, Harper RW, Hauser KL, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Smith GF, Takeuchi K, Thrasher KJ, Tinsley JM, Utterback BG, Yan SC, Zhang M. Sall DJ, et al. Among authors: thrasher kj. J Med Chem. 1997 Oct 24;40(22):3489-93. doi: 10.1021/jm9704107. J Med Chem. 1997. PMID: 9357512 No abstract available.
Quinazolinone cholecystokinin-B receptor ligands.
Yu MJ, Thrasher KJ, McCowan JR, Mason NR, Mendelsohn LG. Yu MJ, et al. Among authors: thrasher kj. J Med Chem. 1991 Apr;34(4):1505-8. doi: 10.1021/jm00108a040. J Med Chem. 1991. PMID: 2016728 No abstract available.
Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator.
Palkowitz AD, Glasebrook AL, Thrasher KJ, Hauser KL, Short LL, Phillips DL, Muehl BS, Sato M, Shetler PK, Cullinan GJ, Pell TR, Bryant HU. Palkowitz AD, et al. Among authors: thrasher kj. J Med Chem. 1997 May 9;40(10):1407-16. doi: 10.1021/jm970167b. J Med Chem. 1997. PMID: 9154963
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Fales KR, Njoroge FG, Brooks HB, Thibodeaux S, Torrado A, Si C, Toth JL, Mc Cowan JR, Roth KD, Thrasher KJ, Frimpong K, Lee MR, Dally RD, Shepherd TA, Durham TB, Margolis BJ, Wu Z, Wang Y, Atwell S, Wang J, Hui YH, Meier TI, Konicek SA, Geeganage S. Fales KR, et al. Among authors: thrasher kj. J Med Chem. 2017 Dec 14;60(23):9599-9616. doi: 10.1021/acs.jmedchem.7b01046. Epub 2017 Nov 9. J Med Chem. 2017. PMID: 29072452
Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues.
Evers B, Ruehter G, Berg M, Dodge JA, Hankotius D, Hary U, Jungheim LN, Mest HJ, de la Nava EM, Mohr M, Muehl BS, Petersen S, Sommer B, Riedel-Herold G, Tebbe MJ, Thrasher KJ, Voelkers S. Evers B, et al. Among authors: thrasher kj. Bioorg Med Chem. 2005 Dec 15;13(24):6748-62. doi: 10.1016/j.bmc.2005.07.070. Epub 2005 Oct 10. Bioorg Med Chem. 2005. PMID: 16219466
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Brooks HB, Meier TI, Geeganage S, Fales KR, Thrasher KJ, Konicek SA, Spencer CD, Thibodeaux S, Foreman RT, Hui YH, Roth KD, Qian YW, Wang T, Luo S, Torrado A, Si C, Toth JL, Mc Cowan JR, Frimpong K, Lee MR, Dally RD, Shepherd TA, Durham TB, Wang Y, Wu Z, Iversen PW, Njoroge FG. Brooks HB, et al. Among authors: thrasher kj. Sci Rep. 2018 Oct 18;8(1):15458. doi: 10.1038/s41598-018-33453-4. Sci Rep. 2018. PMID: 30337562 Free PMC article.
Parasympathetic innervation of the rat cornea.
Marfurt CF, Jones MA, Thrasher K. Marfurt CF, et al. Exp Eye Res. 1998 Apr;66(4):437-48. doi: 10.1006/exer.1997.0445. Exp Eye Res. 1998. PMID: 9593637