Borchelt DR - Search Results

1

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK. Carlson GA, et al. Among authors: borchelt dr. Hum Mol Genet. 1997 Oct;6(11):1951-9. doi: 10.1093/hmg/6.11.1951. Hum Mol Genet. 1997. PMID: 9302276

2

Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D, et al. Hsiao KK, et al. Among authors: borchelt dr. Neuron. 1995 Nov;15(5):1203-18. doi: 10.1016/0896-6273(95)90107-8. Neuron. 1995. PMID: 7576662 Free article.

3

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.

Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA. Iadecola C, et al. Among authors: borchelt dr. Nat Neurosci. 1999 Feb;2(2):157-61. doi: 10.1038/5715. Nat Neurosci. 1999. PMID: 10195200

4

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: borchelt dr. Hum Mol Genet. 2004 Jan 15;13(2):159-70. doi: 10.1093/hmg/ddh019. Epub 2003 Nov 25. Hum Mol Genet. 2004. PMID: 14645205

5

Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice.

Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: borchelt dr. J Biol Chem. 2007 Aug 3;282(31):22707-20. doi: 10.1074/jbc.M611050200. Epub 2007 Jun 7. J Biol Chem. 2007. PMID: 17556372 Free PMC article.

6

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.

Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS. Borchelt DR, et al. Neuron. 1996 Nov;17(5):1005-13. doi: 10.1016/s0896-6273(00)80230-5. Neuron. 1996. PMID: 8938131 Free article.

7

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Jankowsky JL, et al. Among authors: borchelt dr. PLoS Med. 2005 Dec;2(12):e355. doi: 10.1371/journal.pmed.0020355. Epub 2005 Nov 15. PLoS Med. 2005. PMID: 16279840 Free PMC article.

8

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. Davis JA, et al. Among authors: borchelt dr. Neuron. 1998 Mar;20(3):603-9. doi: 10.1016/s0896-6273(00)80998-8. Neuron. 1998. PMID: 9539132 Free article.

9

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease.

Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Jankowsky JL, et al. Among authors: borchelt dr. J Neurosci. 2005 May 25;25(21):5217-24. doi: 10.1523/JNEUROSCI.5080-04.2005. J Neurosci. 2005. PMID: 15917461 Free PMC article.

10

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR. Lesuisse C, et al. Among authors: borchelt dr. Hum Mol Genet. 2001 Oct 15;10(22):2525-37. doi: 10.1093/hmg/10.22.2525. Hum Mol Genet. 2001. PMID: 11709540

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