Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment.
van De Water B, Wang Y, Asmellash S, Liu H, Zhan Y, Miller E, Stevens JL.
van De Water B, et al. Among authors: liu h.
Chem Res Toxicol. 1999 Oct;12(10):943-51. doi: 10.1021/tx990054q.
Chem Res Toxicol. 1999.
PMID: 10525270
Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which is prevented by prior activation of the ER stress response (pre-ER stress) [Liu, H., et al. (1997) J. Biol. Chem. 272, 21751- …
Iodoacetamide (IDAM), a prototypical alkyating agent, induces both Grp and Hsp synthesis in renal epithelial cells and causes necrosis which …