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Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists.
Witte DG, Brune ME, Katwala SP, Milicic I, Stolarik D, Hui YH, Marsh KC, Kerwin JF Jr, Meyer MD, Hancock AA. Witte DG, et al. Among authors: hancock aa. J Pharmacol Exp Ther. 2002 Feb;300(2):495-504. doi: 10.1124/jpet.300.2.495. J Pharmacol Exp Ther. 2002. PMID: 11805209
Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine.
Hancock AA, Buckner SA, Giardina WJ, Brune ME, Lee JY, Morse PA, Oheim KW, Stanisic DS, Warner RB, Kerkman DJ, et al. Hancock AA, et al. J Pharmacol Exp Ther. 1995 Mar;272(3):1160-9. J Pharmacol Exp Ther. 1995. PMID: 7891328
116 results