Friedlos F - Search Results

1

Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.

Green NK, Youngs DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM, Michael NP, Melton RG, Ford MJ, Young LS, Kerr DJ, Searle PF. Green NK, et al. Among authors: friedlos f. Cancer Gene Ther. 1997 Jul-Aug;4(4):229-38. Cancer Gene Ther. 1997. PMID: 9253508

2

Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase.

Friedlos F, Court S, Ford M, Denny WA, Springer C. Friedlos F, et al. Gene Ther. 1998 Jan;5(1):105-12. doi: 10.1038/sj.gt.3300569. Gene Ther. 1998. PMID: 9536271

3

Sensitisation of human ovarian cancer cells to killing by the prodrug CB1954 following retroviral or adenoviral transfer of the E. coli nitroreductase gene.

Searle PF, Weedon SJ, McNeish IA, Gilligan MG, Ford MJ, Friedlos F, Springer CJ, Young LS, Kerr DJ. Searle PF, et al. Among authors: friedlos f. Adv Exp Med Biol. 1998;451:107-13. doi: 10.1007/978-1-4615-5357-1_17. Adv Exp Med Biol. 1998. PMID: 10026858 No abstract available.

4

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Anlezark GM, Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A. Anlezark GM, et al. Among authors: friedlos f. Biochem Pharmacol. 1995 Aug 25;50(5):609-18. doi: 10.1016/0006-2952(95)00187-5. Biochem Pharmacol. 1995. PMID: 7669063

5

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1995 May 26;49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. Biochem Pharmacol. 1995. PMID: 7786305

6

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Boland MP. Knox RJ, et al. Among authors: friedlos f. Cancer Metastasis Rev. 1993 Jun;12(2):195-212. doi: 10.1007/BF00689810. Cancer Metastasis Rev. 1993. PMID: 8375021 Review.

7

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy.

Friedlos F, Denny WA, Palmer BD, Springer CJ. Friedlos F, et al. J Med Chem. 1997 Apr 11;40(8):1270-5. doi: 10.1021/jm960794l. J Med Chem. 1997. PMID: 9111301

8

Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.

Bailey SM, Wyatt MD, Friedlos F, Hartley JA, Knox RJ, Lewis AD, Workman P. Bailey SM, et al. Among authors: friedlos f. Br J Cancer. 1997;76(12):1596-603. doi: 10.1038/bjc.1997.603. Br J Cancer. 1997. PMID: 9413948 Free PMC article.

9

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

Niculescu-Duvaz I, Friedlos F, Niculescu-Duvaz D, Davies L, Springer CJ. Niculescu-Duvaz I, et al. Among authors: friedlos f. Anticancer Drug Des. 1999 Dec;14(6):517-38. Anticancer Drug Des. 1999. PMID: 10834273 Review.

10

In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.

Spooner RA, Martin J, Friedlos F, Marais R, Springer CJ. Spooner RA, et al. Among authors: friedlos f. Cancer Gene Ther. 2000 Oct;7(10):1348-56. doi: 10.1038/sj.cgt.7700243. Cancer Gene Ther. 2000. PMID: 11059693

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