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Page 1
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Hamby JM, Connolly CJ, Schroeder MC, Winters RT, Showalter HD, Panek RL, Major TC, Olsewski B, Ryan MJ, Dahring T, Lu GH, Keiser J, Amar A, Shen C, Kraker AJ, Slintak V, Nelson JM, Fry DW, Bradford L, Hallak H, Doherty AM. Hamby JM, et al. Among authors: connolly cj. J Med Chem. 1997 Jul 18;40(15):2296-303. doi: 10.1021/jm970367n. J Med Chem. 1997. PMID: 9240345
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).
Sircar I, Hodges JC, Quin J 3rd, Bunker AM, Winters RT, Edmunds JJ, Kostlan CR, Connolly C, Kesten SJ, Hamby JM, et al. Sircar I, et al. J Med Chem. 1993 Aug 6;36(16):2253-65. doi: 10.1021/jm00068a002. J Med Chem. 1993. PMID: 8360871
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase.
Thompson AM, Connolly CJ, Hamby JM, Boushelle S, Hartl BG, Amar AM, Kraker AJ, Driscoll DL, Steinkampf RW, Patmore SJ, Vincent PW, Roberts BJ, Elliott WL, Klohs W, Leopold WR, Showalter HD, Denny WA. Thompson AM, et al. Among authors: connolly cj. J Med Chem. 2000 Nov 2;43(22):4200-11. doi: 10.1021/jm000161d. J Med Chem. 2000. PMID: 11063616
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.
Schroeder MC, Hamby JM, Connolly CJ, Grohar PJ, Winters RT, Barvian MR, Moore CW, Boushelle SL, Crean SM, Kraker AJ, Driscoll DL, Vincent PW, Elliott WL, Lu GH, Batley BL, Dahring TK, Major TC, Panek RL, Doherty AM, Showalter HD. Schroeder MC, et al. Among authors: connolly cj. J Med Chem. 2001 Jun 7;44(12):1915-26. doi: 10.1021/jm0004291. J Med Chem. 2001. PMID: 11384237
30 results