Hamel E - Search Results

1

Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Chen K, Kuo SC, Hsieh MC, Mauger A, Lin CM, Hamel E, Lee KH. Chen K, et al. Among authors: hamel e. J Med Chem. 1997 Jul 4;40(14):2266-75. doi: 10.1021/jm960858s. J Med Chem. 1997. PMID: 9216846

2

Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.

Getahun Z, Jurd L, Chu PS, Lin CM, Hamel E. Getahun Z, et al. Among authors: hamel e. J Med Chem. 1992 Mar 20;35(6):1058-67. doi: 10.1021/jm00084a011. J Med Chem. 1992. PMID: 1552500

3

Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents.

Cushman M, Nagarathnam D, Gopal D, He HM, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1992 Jun 12;35(12):2293-306. doi: 10.1021/jm00090a021. J Med Chem. 1992. PMID: 1613753

4

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

Paull KD, Lin CM, Malspeis L, Hamel E. Paull KD, et al. Among authors: hamel e. Cancer Res. 1992 Jul 15;52(14):3892-900. Cancer Res. 1992. PMID: 1617665

5

Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate.

Hamel E, Lin CM, Kenney S, Skehan P. Hamel E, et al. Arch Biochem Biophys. 1991 Apr;286(1):57-69. doi: 10.1016/0003-9861(91)90008-7. Arch Biochem Biophys. 1991. PMID: 1680309

6

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

Cushman M, Nagarathnam D, Gopal D, Chakraborti AK, Lin CM, Hamel E. Cushman M, et al. Among authors: hamel e. J Med Chem. 1991 Aug;34(8):2579-88. doi: 10.1021/jm00112a036. J Med Chem. 1991. PMID: 1875350

7

Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one.

Lin CM, Kang GJ, Roach MC, Jiang JB, Hesson DP, Luduena RF, Hamel E. Lin CM, et al. Among authors: hamel e. Mol Pharmacol. 1991 Nov;40(5):827-32. Mol Pharmacol. 1991. PMID: 1944246

8

Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

Jiang JB, Hesson DP, Dusak BA, Dexter DL, Kang GJ, Hamel E. Jiang JB, et al. Among authors: hamel e. J Med Chem. 1990 Jun;33(6):1721-8. doi: 10.1021/jm00168a029. J Med Chem. 1990. PMID: 2088342

9

Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids.

Muzaffar A, Brossi A, Lin CM, Hamel E. Muzaffar A, et al. Among authors: hamel e. J Med Chem. 1990 Feb;33(2):567-71. doi: 10.1021/jm00164a015. J Med Chem. 1990. PMID: 2299625

10

Reexamination of the role of nonhydrolyzable guanosine 5'-triphosphate analogues in tubulin polymerization: reaction conditions are a critical factor for effective interactions at the exchangeable nucleotide site.

Hamel E, Lin CM. Hamel E, et al. Biochemistry. 1990 Mar 20;29(11):2720-9. doi: 10.1021/bi00463a015. Biochemistry. 1990. PMID: 2346744

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