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Structure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase.
Sigalapalli DK, Groustra S, Fenwick MK, Zigweid R, Hulverson MA, Owsley E, Khim M, Shibata S, Van Voorhis WC, Staker BL, Fan E. Sigalapalli DK, et al. Bioorg Med Chem Lett. 2025 Jan 6;119:130092. doi: 10.1016/j.bmcl.2025.130092. Online ahead of print. Bioorg Med Chem Lett. 2025. PMID: 39778753
Historical and Archaeogenomic Identification of High-Status Englishmen at Jamestown, Virginia.
Owsley DW, Bruwelheide KS, Harney É, Mallick S, Rohland N, Olalde I, Barca KG, Ramsey AJ, Hull-Walski DA, Kelso WM, May JE, Broomandkhoshbacht N, Ferry M, Lawson AM, Michel M, Oppenheimer J, Stewardson K, Zalzala F, Simon VE, Givens DM, Lavin MD, Reich DE. Owsley DW, et al. Antiquity. 2024 Aug;98(400):1040-1054. doi: 10.15184/aqy.2024.75. Epub 2024 Aug 13. Antiquity. 2024. PMID: 39697469 Free PMC article.
548 results