De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS.
Panjarian S, et al. Among authors: dbaibo gs.
Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):41-8. doi: 10.1016/j.prostaglandins.2008.02.004. Epub 2008 Mar 4.
Prostaglandins Other Lipid Mediat. 2008.
PMID: 18400537
Previously we had shown that, in a p53-dependent model of cell death, ceramide accumulated in a p53-dependent manner [Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, Hannun YA. J Clin Invest 1998;102:329-339]. ...
Previously we had shown that, in a p53-dependent model of cell death, ceramide accumulated in a p53-dependent manner [Dbaibo GS …