Kirchner T - Search Results

1

N-(5-substituted) thiophene-2-alkylsulfonamides as potent inhibitors of 5-lipoxygenase.

Beers SA, Malloy EA, Wu W, Wachter M, Ansell J, Singer M, Steber M, Barbone A, Kirchner T, Ritchie D, Argentieri D. Beers SA, et al. Among authors: kirchner t. Bioorg Med Chem. 1997 Apr;5(4):779-86. doi: 10.1016/s0968-0896(97)00025-4. Bioorg Med Chem. 1997. PMID: 9158876

2

Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile.

Argentieri DC, Ritchie DM, Ferro MP, Kirchner T, Wachter MP, Anderson DW, Rosenthale ME, Capetola RJ. Argentieri DC, et al. Among authors: kirchner t. J Pharmacol Exp Ther. 1994 Dec;271(3):1399-408. J Pharmacol Exp Ther. 1994. PMID: 7996452

3

Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation.

Kirchner T, Argentieri DC, Barbone AG, Singer M, Steber M, Ansell J, Beers SA, Wachter MP, Wu W, Malloy E, Stewart A, Ritchie DM. Kirchner T, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. J Pharmacol Exp Ther. 1997. PMID: 9262379

4

Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation.

Kirchner T, Aparicio B, Argentieri DC, Lau CY, Ritchie DM. Kirchner T, et al. Prostaglandins Leukot Essent Fatty Acids. 1997 Jun;56(6):417-23. doi: 10.1016/s0952-3278(97)90593-7. Prostaglandins Leukot Essent Fatty Acids. 1997. PMID: 9223651

5

In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions.

Hou C, Kirchner T, Singer M, Matheis M, Argentieri D, Cavender D. Hou C, et al. Among authors: kirchner t. J Pharmacol Exp Ther. 2004 May;309(2):697-704. doi: 10.1124/jpet.103.060574. Epub 2004 Jan 16. J Pharmacol Exp Ther. 2004. PMID: 14730005

6

Experimental antiasthmatic activity of RWJ 22108: a bronchoselective calcium entry blocker.

Ritchie DM, Kirchner T, Moore JB, Dodd JH, Ahmed T, Anderson DW, Capetola RJ. Ritchie DM, et al. Among authors: kirchner t. Int Arch Allergy Immunol. 1993;100(3):274-82. doi: 10.1159/000236424. Int Arch Allergy Immunol. 1993. PMID: 8453315

7

Design and discovery of RWJ 22108--a novel bronchoselective calcium channel blocker.

Dodd JH, Schwender CF, Moore JB Jr, Ritchie DM, Gray-Nunez Y, Loughney D, Kirchner T, Miller WC, Mockoviak S. Dodd JH, et al. Among authors: kirchner t. Drug Des Discov. 1998 May;15(3):135-48. Drug Des Discov. 1998. PMID: 9689497

8

Design, synthesis and bronchodilatory activity of a series of quinazoline-3-oxides.

Combs DW, Rampulla MS, Russell RK, Rampulla RA, Klaubert DH, Ritchie D, Meeks AS, Kirchner T. Combs DW, et al. Among authors: kirchner t. Drug Des Deliv. 1990 Oct;6(4):241-54. Drug Des Deliv. 1990. PMID: 2083028

9

Synthesis and biological properties of RWJ 22108, a bronchoselective calcium channel blocker.

Dodd JH, Schwender CF, Conley RA, Moore JB Jr, Ritchie DM, Fabian AC, Fenk CJ, Bourcet E, Gray-Nunez Y, Kirchner T, et al. Dodd JH, et al. Among authors: kirchner t. Drug Des Discov. 1993;10(1):65-75. Drug Des Discov. 1993. PMID: 8399994 No abstract available.

10

Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.

Xu G, Gaul MD, Kuo GH, Du F, Xu JZ, Wallace N, Hinke S, Kirchner T, Silva J, Huebert ND, Lee S, Murray W, Liang Y, Demarest K. Xu G, et al. Among authors: kirchner t. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453. doi: 10.1016/j.bmcl.2018.09.025. Epub 2018 Sep 19. Bioorg Med Chem Lett. 2018. PMID: 30268701

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