Calverley MJ - Search Results

1

Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain.

Shankar VN, Dilworth FJ, Makin HL, Schroeder NJ, Trafford DJ, Kissmeyer AM, Calverley MJ, Binderup E, Jones G. Shankar VN, et al. Among authors: calverley mj. Biochem Pharmacol. 1997 Mar 21;53(6):783-93. doi: 10.1016/s0006-2952(96)00815-5. Biochem Pharmacol. 1997. PMID: 9113099

2

Metabolism of a cyclopropane-ring-containing analog of 1 alpha-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites.

Strugnell S, Calverley MJ, Jones G. Strugnell S, et al. Among authors: calverley mj. Biochem Pharmacol. 1990 Jul 15;40(2):333-41. doi: 10.1016/0006-2952(90)90696-i. Biochem Pharmacol. 1990. PMID: 2375769

3

Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism.

Dilworth FJ, Scott I, Green A, Strugnell S, Guo YD, Roberts EA, Kremer R, Calverley MJ, Makin HL, Jones G. Dilworth FJ, et al. Among authors: calverley mj. J Biol Chem. 1995 Jul 14;270(28):16766-74. doi: 10.1074/jbc.270.28.16766. J Biol Chem. 1995. PMID: 7622489 Free article.

4

In vitro metabolism of the anti-psoriatic vitamin D analog, calcipotriol, in two cultured human keratinocyte models.

Masuda S, Strugnell S, Calverley MJ, Makin HL, Kremer R, Jones G. Masuda S, et al. Among authors: calverley mj. J Biol Chem. 1994 Feb 18;269(7):4794-803. J Biol Chem. 1994. PMID: 8106449 Free article.

5

Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding.

Dilworth FJ, Calverley MJ, Makin HL, Jones G. Dilworth FJ, et al. Among authors: calverley mj. Biochem Pharmacol. 1994 Mar 15;47(6):987-93. doi: 10.1016/0006-2952(94)90409-x. Biochem Pharmacol. 1994. PMID: 8147918

6

In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha,25- and 1 beta,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity.

Qaw F, Calverley MJ, Schroeder NJ, Trafford DJ, Makin HL, Jones G. Qaw F, et al. Among authors: calverley mj. J Biol Chem. 1993 Jan 5;268(1):282-92. J Biol Chem. 1993. PMID: 8380156 Free article.

7

The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity.

Dilworth FJ, Williams GR, Kissmeyer AM, Nielsen JL, Binderup E, Calverley MJ, Makin HL, Jones G. Dilworth FJ, et al. Among authors: calverley mj. Endocrinology. 1997 Dec;138(12):5485-96. doi: 10.1210/endo.138.12.5594. Endocrinology. 1997. PMID: 9389535

8

The metabolism of dihydrotachysterols: renal side chain and non-renal nuclear hydroxylations in vivo and in vitro.

Qaw F, Schroeder NJ, Calverley MJ, Trafford DJ, Makin HL, Jones G. Qaw F, et al. Among authors: calverley mj. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):859-70. doi: 10.1016/0960-0760(92)90439-p. J Steroid Biochem Mol Biol. 1992. PMID: 1562563

9

Polar metabolites of dihydrotachysterol3 in the rat. Comparison with in vitro metabolites of 1 alpha,25-dihydroxydihydrotachysterol3.

Schroeder NJ, Qaw F, Calverley MJ, Trafford DJ, Jones G, Makin HL. Schroeder NJ, et al. Among authors: calverley mj. Biochem Pharmacol. 1992 May 8;43(9):1893-905. doi: 10.1016/0006-2952(92)90631-r. Biochem Pharmacol. 1992. PMID: 1596278

10

A dialogue on analogues Newer vitamin-D drugs for use in bone disease, psoriasis, and cancer.

Jones G, Calverley MJ. Jones G, et al. Among authors: calverley mj. Trends Endocrinol Metab. 1993 Nov;4(9):297-303. doi: 10.1016/1043-2760(93)90049-k. Trends Endocrinol Metab. 1993. PMID: 18407173

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