Upthagrove AL - Search Results

1

(E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays.

Palmer RB, Upthagrove AL, Nelson WL. Palmer RB, et al. Among authors: upthagrove al. J Med Chem. 1997 Feb 28;40(5):749-53. doi: 10.1021/jm960573f. J Med Chem. 1997. PMID: 9057861

2

Fragmentation pathways of selectively labeled uropranolol using electrospray ionization on an ion trap mass spectrometer and comparison with ions formed by electron impact.

Upthagrove AL, Hackett M, Nelson WL. Upthagrove AL, et al. Rapid Commun Mass Spectrom. 1999;13(6):534-41. doi: 10.1002/(SICI)1097-0231(19990330)13:6<534::AID-RCM520>3.0.CO;2-F. Rapid Commun Mass Spectrom. 1999. PMID: 10204247

3

Mass spectral fragmentation pathways of propranolol related beta-fluorinated amines studied by electrospray and electron impact ionization.

Upthagrove AL, Hackett M, Nelson WL. Upthagrove AL, et al. Rapid Commun Mass Spectrom. 1999;13(16):1671-9. doi: 10.1002/(SICI)1097-0231(19990830)13:16<1671::AID-RCM696>3.0.CO;2-V. Rapid Commun Mass Spectrom. 1999. PMID: 10440986

4

Carbinolamines, imines, and oxazolidines from fluorinated propranolol analogs. (19)F NMR and mass spectral characterization and evidence for formation as intermediates in cytochrome P450-catalyzed N-dealkylation.

Upthagrove AL, Nelson WL. Upthagrove AL, et al. Drug Metab Dispos. 2001 Aug;29(8):1114-22. Drug Metab Dispos. 2001. PMID: 11454730

5

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6.

Upthagrove AL, Nelson WL. Upthagrove AL, et al. Drug Metab Dispos. 2001 Nov;29(11):1377-88. Drug Metab Dispos. 2001. PMID: 11602512

6

Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2.

Upthagrove AL, Nelson WL. Upthagrove AL, et al. Drug Metab Dispos. 2001 Nov;29(11):1389-95. Drug Metab Dispos. 2001. PMID: 11602513

7

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

Jiang J, Bunda JL, Doss GA, Chicchi GG, Kurtz MM, Tsao KL, Tong X, Zheng S, Upthagrove A, Samuel K, Tschirret-Guth R, Kumar S, Wheeldon A, Carlson EJ, Hargreaves R, Burns D, Hamill T, Ryan C, Krause SM, Eng W, DeVita RJ, Mills SG. Jiang J, et al. J Med Chem. 2009 May 14;52(9):3039-46. doi: 10.1021/jm8016514. J Med Chem. 2009. PMID: 19354254

8

Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.

Yu H, Balani SK, Chen W, Cui D, He L, Humphreys WG, Mao J, Lai WG, Lee AJ, Lim HK, MacLauchlin C, Prakash C, Surapaneni S, Tse S, Upthagrove A, Walsky RL, Wen B, Zeng Z. Yu H, et al. Drug Metab Dispos. 2015 Apr;43(4):620-30. doi: 10.1124/dmd.114.059345. Epub 2015 Feb 5. Drug Metab Dispos. 2015. PMID: 25655830

9

Pradigastat disposition in humans: in vivo and in vitro investigations.

Upthagrove A, Chen J, Meyers CD, Kulmatycki K, Bretz A, Wang L, Peng L, Palamar S, Lin M, Majumdar T, Tran P, Einolf HJ. Upthagrove A, et al. Xenobiotica. 2017 Dec;47(12):1077-1089. doi: 10.1080/00498254.2016.1263405. Epub 2016 Dec 12. Xenobiotica. 2017. PMID: 27855567

10

Lewis-acid catalysis of photochemical reactions. 6. Selective isomerization of .beta.-furylacrylic and urocanic esters.

Lewis FD, Howard DK, Oxman JD, Upthagrove AL, Quillen SL. Lewis FD, et al. Among authors: upthagrove al. J Am Chem Soc. 1986 Sep 1;108(19):5964-8. doi: 10.1021/ja00279a049. J Am Chem Soc. 1986. PMID: 22175357 No abstract available.

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