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Systemic delivery of human growth hormone or human factor IX in dogs by reintroduced genetically modified autologous bone marrow stromal cells.
Hurwitz DR, Kirchgesser M, Merrill W, Galanopoulos T, McGrath CA, Emami S, Hansen M, Cherington V, Appel JM, Bizinkauskas CB, Brackmann HH, Levine PH, Greenberger JS. Hurwitz DR, et al. Among authors: greenberger js. Hum Gene Ther. 1997 Jan 20;8(2):137-56. doi: 10.1089/hum.1997.8.2-137. Hum Gene Ther. 1997. PMID: 9017418
Retroviral vector-modified bone marrow stromal cells secrete biologically active factor IX in vitro and transiently deliver therapeutic levels of human factor IX to the plasma of dogs after reinfusion.
Cherington V, Chiang GG, McGrath CA, Gaffney A, Galanopoulos T, Merrill W, Bizinkauskas CB, Hansen M, Sobolewski J, Levine PH, Greenberger JS, Hurwitz DR. Cherington V, et al. Among authors: greenberger js. Hum Gene Ther. 1998 Jul 1;9(10):1397-407. doi: 10.1089/hum.1998.9.10-1397. Hum Gene Ther. 1998. PMID: 9681411
Bone marrow stromal cell-mediated gene therapy for hemophilia A: in vitro expression of human factor VIII with high biological activity requires the inclusion of the proteolytic site at amino acid 1648.
Chiang GG, Rubin HL, Cherington V, Wang T, Sobolewski J, McGrath CA, Gaffney A, Emami S, Sarver N, Levine PH, Greenberger JS, Hurwitz DR. Chiang GG, et al. Among authors: greenberger js. Hum Gene Ther. 1999 Jan 1;10(1):61-76. doi: 10.1089/10430349950019192. Hum Gene Ther. 1999. PMID: 10022531
476 results