Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.
Giannelli V, Fontana MR, Giuliani MM, Guangcai D, Rappuoli R, Pizza M.
Giannelli V, et al. Among authors: pizza m.
Infect Immun. 1997 Jan;65(1):331-4. doi: 10.1128/iai.65.1.331-334.1997.
Infect Immun. 1997.
PMID: 8975934
Free PMC article.
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either the amino acid residues located in the catalytic site (M. Pizza, M. Domenighini, W. Hol, V. Giannelli, M. R. Fon …
To generate nontoxic derivatives of Escherichia coli heat-labile enterotoxin (LT), site-directed mutagenesis has been used to change either …