Goldfarb PS - Search Results

1

Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals.

Lewis DF, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1996 Oct;26(10):1067-86. doi: 10.3109/00498259609167423. Xenobiotica. 1996. PMID: 8905920

2

An evaluation of ondansetron binding interactions with human cytochrome P450 enzymes CYP3A4 and CYP2D6.

Lewis DF, Ito Y, Eddershaw PJ, Dickins M, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Drug Metab Lett. 2010 Jan;4(1):25-30. doi: 10.2174/187231210790980408. Drug Metab Lett. 2010. PMID: 20201779

3

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.

Lewis DF, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1997 Apr;27(4):319-39. doi: 10.1080/004982597240497. Xenobiotica. 1997. PMID: 9149373

4

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.

Lewis DF, Dickins M, Weaver RJ, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1998 Mar;28(3):235-68. doi: 10.1080/004982598239542. Xenobiotica. 1998. PMID: 9574814

5

Structural determinants of cytochrome P450 substrate specificity, binding affinity and catalytic rate.

Lewis DF, Eddershaw PJ, Dickins M, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Chem Biol Interact. 1998 Oct 2;115(3):175-99. doi: 10.1016/s0009-2797(98)00068-4. Chem Biol Interact. 1998. PMID: 9851289 Review.

6

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Ogg MS, Williams JM, Tarbit M, Goldfarb PS, Gray TJ, Gibson GG. Ogg MS, et al. Among authors: goldfarb ps. Xenobiotica. 1999 Mar;29(3):269-79. doi: 10.1080/004982599238669. Xenobiotica. 1999. PMID: 10219967

7

Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.

Lewis DF, Lake BG, Dickins M, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 1999 Apr;29(4):361-93. doi: 10.1080/004982599238560. Xenobiotica. 1999. PMID: 10375007

8

Molecular modelling of the human cytochrome P450 isoform CYP2A6 and investigations of CYP2A substrate selectivity.

Lewis DF, Dickins M, Lake BG, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Toxicology. 1999 Mar 1;133(1):1-33. doi: 10.1016/s0300-483x(98)00149-8. Toxicology. 1999. PMID: 10413191

9

Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.

Lewis DF, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP. Lewis DF, et al. Among authors: goldfarb ps. Toxicology. 1999 Nov 29;139(1-2):53-79. doi: 10.1016/s0300-483x(99)00098-0. Toxicology. 1999. PMID: 10614688

10

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform.

Lewis DF, Bird MG, Dickins M, Lake BG, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Among authors: goldfarb ps. Xenobiotica. 2000 Jan;30(1):1-25. doi: 10.1080/004982500237794. Xenobiotica. 2000. PMID: 10659948

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