Marino AM - Search Results

1

Prodrugs of BMS-183920: metabolism and permeability considerations.

Obermeier MT, Chong S, Dando SA, Marino AM, Ryono DE, Starrett-Arroyo A, DiDonato GC, Warrack BM, White RE, Morrison RA. Obermeier MT, et al. Among authors: marino am. J Pharm Sci. 1996 Aug;85(8):828-33. doi: 10.1021/js9600282. J Pharm Sci. 1996. PMID: 8863272

2

Distribution of the dipeptide transporter system along the gastrointestinal tract of rats based on absorption of a stable and specific probe, SQ-29852.

Marino AM, Chong S, Dando SA, Kripalani KJ, Bathala MS, Morrison RA. Marino AM, et al. J Pharm Sci. 1996 Mar;85(3):282-6. doi: 10.1021/js950017t. J Pharm Sci. 1996. PMID: 8699329

3

Suitability of enalapril as a probe of the dipeptide transporter system: in vitro and in vivo studies.

Morrison RA, Chong S, Marino AM, Wasserman MA, Timmins P, Moore VA, Irwin WJ. Morrison RA, et al. Among authors: marino am. Pharm Res. 1996 Jul;13(7):1078-82. doi: 10.1023/a:1016071027177. Pharm Res. 1996. PMID: 8842049

4

Intestinal absorption of captopril and two thioester analogs in rats and dogs.

Morrison RA, Kripalani KJ, Marino AM, Dean AV, Migdalof BH, Weinstein SH, Jain NB, Bathala MS, Singhvi SM. Morrison RA, et al. Among authors: marino am. Biopharm Drug Dispos. 1997 Jan;18(1):25-39. doi: 10.1002/(sici)1099-081x(199701)18:1<25::aid-bdd998>3.0.co;2-t. Biopharm Drug Dispos. 1997. PMID: 9008267

5

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

Murugesan N, Gu Z, Stein PD, Spergel S, Mathur A, Leith L, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Morrison RA, Webb ML, Moreland S, Barrish JC. Murugesan N, et al. J Med Chem. 2000 Aug 10;43(16):3111-7. doi: 10.1021/jm000105c. J Med Chem. 2000. PMID: 10956219

6

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Murugesan N, Gu Z, Spergel S, Young M, Chen P, Mathur A, Leith L, Hermsmeier M, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Koplowitz B, Humphreys WG, Chong S, Morrison RA, Webb ML, Moreland S, Trippodo N, Barrish JC. Murugesan N, et al. J Med Chem. 2003 Jan 2;46(1):125-37. doi: 10.1021/jm020289q. J Med Chem. 2003. PMID: 12502366

7

Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties.

Humphreys WG, Obermeier MT, Barrish JC, Chong S, Marino AM, Murugesan N, Wang-Iverson D, Morrison RA. Humphreys WG, et al. Among authors: marino am. Xenobiotica. 2003 Nov;33(11):1109-23. doi: 10.1080/00498250310001609147. Xenobiotica. 2003. PMID: 14660175

8

Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery.

Balimane PV, Patel K, Marino A, Chong S. Balimane PV, et al. Eur J Pharm Biopharm. 2004 Jul;58(1):99-105. doi: 10.1016/j.ejpb.2004.02.014. Eur J Pharm Biopharm. 2004. PMID: 15207543

9

Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux.

Kamath AV, Morrison RA, Harper TW, Lan SJ, Marino AM, Chong S. Kamath AV, et al. Among authors: marino am. J Pharm Sci. 2005 May;94(5):1115-23. doi: 10.1002/jps.20278. J Pharm Sci. 2005. PMID: 15793809

10

Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds.

Marino AM, Yarde M, Patel H, Chong S, Balimane PV. Marino AM, et al. Int J Pharm. 2005 Jun 13;297(1-2):235-41. doi: 10.1016/j.ijpharm.2005.03.008. Epub 2005 Apr 11. Int J Pharm. 2005. PMID: 15907606

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