Brown TJ - Search Results

1

New low-density lipoprotein receptor upregulators acting via a novel mechanism.

Ashton MJ, Brown TJ, Fenton G, Halley F, Harper MF, Lockey PM, Porter B, Roach AG, Stuttle KA, Vicker N, Walsh RJ. Ashton MJ, et al. Among authors: brown tj. J Med Chem. 1996 Aug 16;39(17):3343-56. doi: 10.1021/jm960153q. J Med Chem. 1996. PMID: 8765518

2

Syntheses and biological activities of potent potassium channel openers derived from (+/-)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers.

Brown TJ, Chapman RF, Mason JS, Palfreyman MN, Vicker N, Walsh RJ. Brown TJ, et al. J Med Chem. 1993 May 28;36(11):1604-12. doi: 10.1021/jm00063a010. J Med Chem. 1993. PMID: 8496928

3

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: brown tj. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

4

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. Among authors: brown tj. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

5

Identification of a non peptidic RANTES antagonist.

Bright C, Brown TJ, Cox P, Halley F, Lockey P, McLay IM, Moore U, Porter B, Williams RJ. Bright C, et al. Among authors: brown tj. Bioorg Med Chem Lett. 1998 Apr 7;8(7):771-4. doi: 10.1016/s0960-894x(98)00094-8. Bioorg Med Chem Lett. 1998. PMID: 9871539

6

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: brown tj. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

7

Synthesis and biological activity of trans(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogues: a new class of potassium channel opener.

Brown TJ, Chapman RF, Cook DC, Hart TW, McLay IM, Jordan R, Mason JS, Palfreyman MN, Walsh RJ, Withnall MT, et al. Brown TJ, et al. J Med Chem. 1992 Oct 2;35(20):3613-24. doi: 10.1021/jm00098a004. J Med Chem. 1992. PMID: 1433171

8

Sarafotoxin S6c elicits a non-ETA or non-ETB-mediated pressor response in the pithed rat.

Flynn DA, Sargent CA, Brazdil R, Brown TJ, Roach AG. Flynn DA, et al. Among authors: brown tj. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S219-21. J Cardiovasc Pharmacol. 1995. PMID: 8587368

9

Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats.

Sargent CA, Brazdil R, Flynn DA, Brown TJ, Roach AG. Sargent CA, et al. Among authors: brown tj. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8. J Cardiovasc Pharmacol. 1995. PMID: 8587367

10

In vitro expression of endothelin-1 (ET-1) and the ETA and ETB ET receptors by the prostatic epithelium and stroma.

Grant ES, Brown T, Roach A, Williams BC, Habib FK. Grant ES, et al. J Clin Endocrinol Metab. 1997 Feb;82(2):508-13. doi: 10.1210/jcem.82.2.3724. J Clin Endocrinol Metab. 1997. PMID: 9024245

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