Mutation of Tyr138 disrupts the structural coupling between the opposing domains in vertebrate calmodulin.
Sun H, Yin D, Coffeen LA, Shea MA, Squier TC.
Sun H, et al. Among authors: yin d.
Biochemistry. 2001 Aug 14;40(32):9605-17. doi: 10.1021/bi0104266.
Biochemistry. 2001.
PMID: 11583160
A double mutant was constructed involving conservative substitution of Tyr99 --> Trp99 and Leu69 --> Cys69 to assess the structural coupling between the opposing domains, as previously described [Sun, H., Yin, D., and Squier, T. C. (1999) Biochemistry 38, 1226 …
A double mutant was constructed involving conservative substitution of Tyr99 --> Trp99 and Leu69 --> Cys69 to assess the structural co …