Humblet C - Search Results

1

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: humblet c. Structure. 1996 Apr 15;4(4):375-86. doi: 10.1016/s0969-2126(96)00043-3. Structure. 1996. PMID: 8740360 Free article.

2

Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: humblet c. Drug Des Discov. 1996 Apr;13(3-4):3-14. Drug Des Discov. 1996. PMID: 8874040

3

Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.

Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Parker MH, et al. Among authors: humblet c. Biochemistry. 1999 Oct 12;38(41):13592-601. doi: 10.1021/bi991222g. Biochemistry. 1999. PMID: 10521266

4

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. Pavlovsky AG, et al. Among authors: humblet c. Protein Sci. 1999 Jul;8(7):1455-62. doi: 10.1110/ps.8.7.1455. Protein Sci. 1999. PMID: 10422833 Free PMC article.

5

X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.

Cooper J, Quail W, Frazao C, Foundling SI, Blundell TL, Humblet C, Lunney EA, Lowther WT, Dunn BM. Cooper J, et al. Among authors: humblet c. Biochemistry. 1992 Sep 8;31(35):8142-50. doi: 10.1021/bi00150a005. Biochemistry. 1992. PMID: 1525155

6

Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors.

Trumpp-Kallmeyer S, Rubin JR, Humblet C, Hamby JM, Showalter HD. Trumpp-Kallmeyer S, et al. Among authors: humblet c. J Med Chem. 1998 May 21;41(11):1752-63. doi: 10.1021/jm970634p. J Med Chem. 1998. PMID: 9599227

7

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.

Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hamilton HW, Hagen SE, Markoski LJ, Steinbaugh BA, Tait BD, Humblet C, Lunney EA, Pavlovsky A, Rubin JR, Ferguson D, Graham N, Holler T, Hupe D, Nouhan C, Tummino PJ, Urumov A, Zeikus E, Zeikus G, Gracheck SJ, Erickson JW, et al. Prasad JV, et al. Among authors: humblet c. Bioorg Med Chem. 1999 Dec;7(12):2775-800. doi: 10.1016/s0968-0896(99)00215-1. Bioorg Med Chem. 1999. PMID: 10658583

8

Molecular modeling of renin inhibitor P2 substituents.

Lunney EA, Humblet CC, Repine JT, Blundell TL, Cooper JB, Sibanda BL. Lunney EA, et al. Among authors: humblet cc. Adv Exp Med Biol. 1991;306:391-4. doi: 10.1007/978-1-4684-6012-4_51. Adv Exp Med Biol. 1991. PMID: 1812735 No abstract available.

9

Bit-string methods for selective compound acquisition.

Rhodes N, Willett P, Dunbar JB Jr, Humblet C. Rhodes N, et al. Among authors: humblet c. J Chem Inf Comput Sci. 2000 Mar;40(2):210-4. doi: 10.1021/ci990428l. J Chem Inf Comput Sci. 2000. PMID: 10761120

10

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.

Shahripour AB, Plummer MS, Lunney EA, Sawyer TK, Stankovic CJ, Connolly MK, Rubin JR, Walker NP, Brady KD, Allen HJ, Talanian RV, Wong WW, Humblet C. Shahripour AB, et al. Among authors: humblet c. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2779-82. doi: 10.1016/s0960-894x(01)00573-x. Bioorg Med Chem Lett. 2001. PMID: 11591522

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