Willson TM - Search Results

1

3-[2-(N-phenylacetamide)]-1,5-benzodiazepines: orally active, binding selective CCK-A agonists.

Willson TM, Henke BR, Momtahen TM, Myers PL, Sugg EE, Unwalla RJ, Croom DK, Dougherty RW, Grizzle MK, Johnson MF, Queen KL, Rimele TJ, Yingling JD, James MK. Willson TM, et al. J Med Chem. 1996 Jul 19;39(15):3030-4. doi: 10.1021/jm960205b. J Med Chem. 1996. PMID: 8709137

2

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.

Willson TM, Henke BR, Momtahen TM, Charifson PS, Batchelor KW, Lubahn DB, Moore LB, Oliver BB, Sauls HR, Triantafillou JA, et al. Willson TM, et al. J Med Chem. 1994 May 27;37(11):1550-2. doi: 10.1021/jm00037a002. J Med Chem. 1994. PMID: 8201587 No abstract available.

3

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.

Willson TM, Cobb JE, Cowan DJ, Wiethe RW, Correa ID, Prakash SR, Beck KD, Moore LB, Kliewer SA, Lehmann JM. Willson TM, et al. J Med Chem. 1996 Feb 2;39(3):665-8. doi: 10.1021/jm950395a. J Med Chem. 1996. PMID: 8576907 No abstract available.

4

3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.

Henke BR, Willson TM, Sugg EE, Croom DK, Dougherty RW Jr, Queen KL, Birkemo LS, Ervin GN, Grizzle MK, Johnson MF, James MK. Henke BR, et al. Among authors: willson tm. J Med Chem. 1996 Jul 5;39(14):2655-8. doi: 10.1021/jm960249k. J Med Chem. 1996. PMID: 8709093 No abstract available.

5

Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.

Hirst GC, Aquino C, Birkemo L, Croom DK, Dezube M, Dougherty RW Jr, Ervin GN, Grizzle MK, Henke B, James MK, Johnson MF, Momtahen T, Queen KL, Sherrill RG, Szewczyk J, Willson TM, Sugg EE. Hirst GC, et al. Among authors: willson tm. J Med Chem. 1996 Dec 20;39(26):5236-45. doi: 10.1021/jm9601664. J Med Chem. 1996. PMID: 8978852

6

Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.

Willson TM, Norris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP. Willson TM, et al. Endocrinology. 1997 Sep;138(9):3901-11. doi: 10.1210/endo.138.9.5358. Endocrinology. 1997. PMID: 9275080

7

Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.

Henke BR, Aquino CJ, Birkemo LS, Croom DK, Dougherty RW Jr, Ervin GN, Grizzle MK, Hirst GC, James MK, Johnson MF, Queen KL, Sherrill RG, Sugg EE, Suh EM, Szewczyk JW, Unwalla RJ, Yingling J, Willson TM. Henke BR, et al. Among authors: willson tm. J Med Chem. 1997 Aug 15;40(17):2706-25. doi: 10.1021/jm970265x. J Med Chem. 1997. PMID: 9276016

8

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

Henke BR, Blanchard SG, Brackeen MF, Brown KK, Cobb JE, Collins JL, Harrington WW Jr, Hashim MA, Hull-Ryde EA, Kaldor I, Kliewer SA, Lake DH, Leesnitzer LM, Lehmann JM, Lenhard JM, Orband-Miller LA, Miller JF, Mook RA Jr, Noble SA, Oliver W Jr, Parks DJ, Plunket KD, Szewczyk JR, Willson TM. Henke BR, et al. Among authors: willson tm. J Med Chem. 1998 Dec 3;41(25):5020-36. doi: 10.1021/jm9804127. J Med Chem. 1998. PMID: 9836620

9

Differential activity of rosiglitazone enantiomers at PPAR gamma.

Parks DJ, Tomkinson NC, Villeneuve MS, Blanchard SG, Willson TM. Parks DJ, et al. Among authors: willson tm. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3657-8. doi: 10.1016/s0960-894x(98)00664-7. Bioorg Med Chem Lett. 1998. PMID: 9934490

10

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM. Brown KK, et al. Among authors: willson tm. Diabetes. 1999 Jul;48(7):1415-24. doi: 10.2337/diabetes.48.7.1415. Diabetes. 1999. PMID: 10389847

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