Keefer LK - Search Results

1

Nitric oxide-releasing polymers containing the [N(O)NO]- group.

Smith DJ, Chakravarthy D, Pulfer S, Simmons ML, Hrabie JA, Citro ML, Saavedra JE, Davies KM, Hutsell TC, Mooradian DL, Hanson SR, Keefer LK. Smith DJ, et al. Among authors: keefer lk. J Med Chem. 1996 Mar 1;39(5):1148-56. doi: 10.1021/jm950652b. J Med Chem. 1996. PMID: 8676352

2

Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor.

Saavedra JE, Southan GJ, Davies KM, Lundell A, Markou C, Hanson SR, Adrie C, Hurford WE, Zapol WM, Keefer LK. Saavedra JE, et al. Among authors: keefer lk. J Med Chem. 1996 Oct 25;39(22):4361-5. doi: 10.1021/jm960616s. J Med Chem. 1996. PMID: 8893830

3

Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin.

Saavedra JE, Mooradian DL, Mowery KA, Schoenfisch MH, Citro ML, Davies KM, Meyerhoff ME, Keefer LK. Saavedra JE, et al. Among authors: keefer lk. Bioorg Med Chem Lett. 2000 Apr 17;10(8):751-3. doi: 10.1016/s0960-894x(00)00086-x. Bioorg Med Chem Lett. 2000. PMID: 10782678

4

Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.

Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA, Keefer LK. Maragos CM, et al. Among authors: keefer lk. J Med Chem. 1991 Nov;34(11):3242-7. doi: 10.1021/jm00115a013. J Med Chem. 1991. PMID: 1956043

5

A nitric oxide-releasing polydiazeniumdiolate derived from acetonitrile.

Arnold EV, Citro ML, Keefer LK, Hrabie JA. Arnold EV, et al. Among authors: keefer lk. Org Lett. 2002 Apr 18;4(8):1323-5. doi: 10.1021/ol025624j. Org Lett. 2002. PMID: 11950353

6

Mechanistic insight into exclusive nitric oxide recovery from a carbon-bound diazeniumdiolate.

Arnold EV, Citro ML, Saavedra EA, Davies KM, Keefer LK, Hrabie JA. Arnold EV, et al. Among authors: keefer lk. Nitric Oxide. 2002 Sep;7(2):103-8. doi: 10.1016/s1089-8603(02)00101-5. Nitric Oxide. 2002. PMID: 12223179

7

Carbon-bound diazeniumdiolates from the reaction of nitric oxide with amidines.

Hrabie JA, Citro ML, Chmurny GN, Keefer LK. Hrabie JA, et al. Among authors: keefer lk. J Org Chem. 2005 Sep 16;70(19):7647-53. doi: 10.1021/jo050921y. J Org Chem. 2005. PMID: 16149795

8

Nitric oxide releasing polyurethanes with covalently linked diazeniumdiolated secondary amines.

Reynolds MM, Hrabie JA, Oh BK, Politis JK, Citro ML, Keefer LK, Meyerhoff ME. Reynolds MM, et al. Among authors: keefer lk. Biomacromolecules. 2006 Mar;7(3):987-94. doi: 10.1021/bm060028o. Biomacromolecules. 2006. PMID: 16529441

9

O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

Velázquez CA, Praveen Rao PN, Citro ML, Keefer LK, Knaus EE. Velázquez CA, et al. Among authors: keefer lk. Bioorg Med Chem. 2007 Jul 15;15(14):4767-74. doi: 10.1016/j.bmc.2007.05.009. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17509888 Free PMC article.

10

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: keefer lk. Org Lett. 2007 Oct 25;9(22):4551-4. doi: 10.1021/ol7019636. Epub 2007 Oct 5. Org Lett. 2007. PMID: 17918856

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