Higgins CF - Search Results

1

Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein.

Goodfellow HR, Sardini A, Ruetz S, Callaghan R, Gros P, McNaughton PA, Higgins CF. Goodfellow HR, et al. Among authors: higgins cf. J Biol Chem. 1996 Jun 7;271(23):13668-74. doi: 10.1074/jbc.271.23.13668. J Biol Chem. 1996. PMID: 8662768 Free article.

2

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding.

Rosenberg MF, Kamis AB, Callaghan R, Higgins CF, Ford RC. Rosenberg MF, et al. Among authors: higgins cf. J Biol Chem. 2003 Mar 7;278(10):8294-9. doi: 10.1074/jbc.M211758200. Epub 2002 Dec 25. J Biol Chem. 2003. PMID: 12501241 Free article.

3

Regulation of volume activated chloride channels by protein kinase C-mediated phosphorylation of P-glycoprotein.

Hardy SP, Valverde MA, Goodfellow HR, Higgins CF, Sepúlveda FV. Hardy SP, et al. Among authors: higgins cf. Jpn J Physiol. 1994;44 Suppl 2:S9-15. Jpn J Physiol. 1994. PMID: 7752561

4

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

Hardy SP, Goodfellow HR, Valverde MA, Gill DR, Sepúlveda V, Higgins CF. Hardy SP, et al. Among authors: higgins cf. EMBO J. 1995 Jan 3;14(1):68-75. doi: 10.1002/j.1460-2075.1995.tb06976.x. EMBO J. 1995. PMID: 7828597 Free PMC article.

5

Interaction of tamoxifen with the multidrug resistance P-glycoprotein.

Callaghan R, Higgins CF. Callaghan R, et al. Among authors: higgins cf. Br J Cancer. 1995 Feb;71(2):294-9. doi: 10.1038/bjc.1995.59. Br J Cancer. 1995. PMID: 7841043 Free PMC article.

6

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

Rosenberg MF, Callaghan R, Ford RC, Higgins CF. Rosenberg MF, et al. Among authors: higgins cf. J Biol Chem. 1997 Apr 18;272(16):10685-94. doi: 10.1074/jbc.272.16.10685. J Biol Chem. 1997. PMID: 9099718 Free article.

7

Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity.

Szabó K, Bakos E, Welker E, Müller M, Goodfellow HR, Higgins CF, Váradi A, Sarkadi B. Szabó K, et al. Among authors: higgins cf. J Biol Chem. 1997 Sep 12;272(37):23165-71. doi: 10.1074/jbc.272.37.23165. J Biol Chem. 1997. PMID: 9287320 Free article.

8

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

Martin C, Berridge G, Higgins CF, Callaghan R. Martin C, et al. Among authors: higgins cf. Br J Pharmacol. 1997 Oct;122(4):765-71. doi: 10.1038/sj.bjp.0701429. Br J Pharmacol. 1997. PMID: 9375975 Free PMC article.

9

Structure of the multidrug resistance P-glycoprotein.

Higgins CF, Callaghan R, Linton KJ, Rosenberg MF, Ford RC. Higgins CF, et al. Semin Cancer Biol. 1997 Jun;8(3):135-42. doi: 10.1006/scbi.1997.0067. Semin Cancer Biol. 1997. PMID: 9441943 Review.

10

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein.

Martin C, Higgins CF, Callaghan R. Martin C, et al. Among authors: higgins cf. Biochemistry. 2001 Dec 25;40(51):15733-42. doi: 10.1021/bi011211z. Biochemistry. 2001. PMID: 11747450

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