Walker RT - Search Results

1

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.

Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI. Hopkins AL, et al. Among authors: walker rt. J Med Chem. 1996 Apr 12;39(8):1589-600. doi: 10.1021/jm960056x. J Med Chem. 1996. PMID: 8648598

2

Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.

Tanaka H, Walker RT, Hopkins AL, Ren J, Jones EY, Fujimoto K, Hayashi M, Miyasaka T, Baba M, Stammers DK, Stuart DI. Tanaka H, et al. Among authors: walker rt. Antivir Chem Chemother. 1998 Jul;9(4):325-32. Antivir Chem Chemother. 1998. PMID: 9875411

3

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1992 Dec 11;35(25):4713-9. doi: 10.1021/jm00103a009. J Med Chem. 1992. PMID: 1469700

4

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1992 Jan 24;35(2):337-45. doi: 10.1021/jm00080a020. J Med Chem. 1992. PMID: 1732552

5

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

Tanaka H, Baba M, Ubasawa M, Takashima H, Sekiya K, Nitta I, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1991 Apr;34(4):1394-9. doi: 10.1021/jm00108a023. J Med Chem. 1991. PMID: 2016715

6

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

Miyasaka T, Tanaka H, Baba M, Hayakawa H, Walker RT, Balzarini J, De Clercq E. Miyasaka T, et al. Among authors: walker rt. J Med Chem. 1989 Dec;32(12):2507-9. doi: 10.1021/jm00132a002. J Med Chem. 1989. PMID: 2479745 No abstract available.

7

Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Inouye N, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1995 Jul 21;38(15):2860-5. doi: 10.1021/jm00015a008. J Med Chem. 1995. PMID: 7636846

8

Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

Tanaka H, Baba M, Saito S, Miyasaka T, Takashima H, Sekiya K, Ubasawa M, Nitta I, Walker RT, Nakashima H, et al. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1991 Apr;34(4):1508-11. doi: 10.1021/jm00108a041. J Med Chem. 1991. PMID: 2016729 No abstract available.

9

Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.

Baba M, Shigeta S, Yuasa S, Takashima H, Sekiya K, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, De Clercq E. Baba M, et al. Among authors: walker rt. Antimicrob Agents Chemother. 1994 Apr;38(4):688-92. doi: 10.1128/AAC.38.4.688. Antimicrob Agents Chemother. 1994. PMID: 7518216 Free PMC article.

10

Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.

Baba M, Yuasa S, Niwa T, Yamamoto M, Yabuuchi S, Takashima H, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, et al. Baba M, et al. Among authors: walker rt. Biochem Pharmacol. 1993 Jun 22;45(12):2507-12. doi: 10.1016/0006-2952(93)90232-l. Biochem Pharmacol. 1993. PMID: 8328988

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