Akhtar M - Search Results

1

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51).

Shyadehi AZ, Lamb DC, Kelly SL, Kelly DE, Schunck WH, Wright JN, Corina D, Akhtar M. Shyadehi AZ, et al. Among authors: akhtar m. J Biol Chem. 1996 May 24;271(21):12445-50. doi: 10.1074/jbc.271.21.12445. J Biol Chem. 1996. PMID: 8647850 Free article.

2

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase).

Lee-Robichaud P, Shyadehi AZ, Wright JN, Akhtar ME, Akhtar M. Lee-Robichaud P, et al. Among authors: akhtar me, akhtar m. Biochemistry. 1995 Oct 31;34(43):14104-13. doi: 10.1021/bi00043a015. Biochemistry. 1995. PMID: 7578007

3

Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: studies on cytochrome P-450(17)alpha.

Akhtar M, Corina D, Miller S, Shyadehi AZ, Wright JN. Akhtar M, et al. Biochemistry. 1994 Apr 12;33(14):4410-8. doi: 10.1021/bi00180a039. Biochemistry. 1994. PMID: 8155659

4

The mutation T315A in Candida albicans sterol 14alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity.

Lamb DC, Kelly DE, Schunck WH, Shyadehi AZ, Akhtar M, Lowe DJ, Baldwin BC, Kelly SL. Lamb DC, et al. Among authors: akhtar m. J Biol Chem. 1997 Feb 28;272(9):5682-8. doi: 10.1074/jbc.272.9.5682. J Biol Chem. 1997. PMID: 9038178 Free article.

5

Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes.

Akhtar M, Njar VC, Wright JN. Akhtar M, et al. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):375-87. doi: 10.1016/0960-0760(93)90241-n. J Steroid Biochem Mol Biol. 1993. PMID: 8476751 Review.

6

Studies on estrogen biosynthesis using radioactive and stable isotopes.

Wright JN, Akhtar M. Wright JN, et al. Among authors: akhtar m. Steroids. 1990 Apr;55(4):142-51. doi: 10.1016/0039-128x(90)90102-h. Steroids. 1990. PMID: 2187283 Review.

7

A unified mechanistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzymes.

Akhtar M, Wright JN. Akhtar M, et al. Nat Prod Rep. 1991 Dec;8(6):527-51. doi: 10.1039/np9910800527. Nat Prod Rep. 1991. PMID: 1784431 Review. No abstract available.

8

Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications.

Lee-Robichaud P, Wright JN, Akhtar ME, Akhtar M. Lee-Robichaud P, et al. Among authors: akhtar me, akhtar m. Biochem J. 1995 Jun 15;308 ( Pt 3)(Pt 3):901-8. doi: 10.1042/bj3080901. Biochem J. 1995. PMID: 8948449 Free PMC article.

9

Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.

Lee-Robichaud P, Kaderbhai MA, Kaderbhai N, Wright JN, Akhtar M. Lee-Robichaud P, et al. Among authors: akhtar m. Biochem J. 1997 Feb 1;321 ( Pt 3)(Pt 3):857-63. doi: 10.1042/bj3210857. Biochem J. 1997. PMID: 9032476 Free PMC article.

10

The impact of aromatase mechanism on other P450s.

Akhtar M, Lee-Robichaud P, Akhtar ME, Wright JN. Akhtar M, et al. Among authors: akhtar me. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):127-32. J Steroid Biochem Mol Biol. 1997. PMID: 9365181

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