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Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).
Lee EC, Desai U, Gololobov G, Hong S, Feng X, Yu XC, Gay J, Wilganowski N, Gao C, Du LL, Chen J, Hu Y, Zhao S, Kirkpatrick L, Schneider M, Zambrowicz BP, Landes G, Powell DR, Sonnenburg WK. Lee EC, et al. J Biol Chem. 2009 May 15;284(20):13735-13745. doi: 10.1074/jbc.M807899200. Epub 2009 Mar 23. J Biol Chem. 2009. PMID: 19318355 Free PMC article.
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR. Desai U, et al. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. doi: 10.1073/pnas.0705041104. Epub 2007 Jul 3. Proc Natl Acad Sci U S A. 2007. PMID: 17609370 Free PMC article.
Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice.
Powell DR, Gay JP, Wilganowski N, Doree D, Savelieva KV, Lanthorn TH, Read R, Vogel P, Hansen GM, Brommage R, Ding ZM, Desai U, Zambrowicz B. Powell DR, et al. Among authors: gay jp. Front Endocrinol (Lausanne). 2015 Jun 2;6:86. doi: 10.3389/fendo.2015.00086. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 26082754 Free PMC article.
Improved glycemic control in mice lacking Sglt1 and Sglt2.
Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, Shadoan MK, Sands AT, Zambrowicz B. Powell DR, et al. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E117-30. doi: 10.1152/ajpendo.00439.2012. Epub 2012 Nov 13. Am J Physiol Endocrinol Metab. 2013. PMID: 23149623 Free article.
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome.
Baugh SD, Pabba PK, Barbosa J, Coulter E, Desai U, Gay JP, Gopinathan S, Han Q, Hari R, Kimball SD, Nguyen HV, Ni CY, Powell DR, Smith A, Terranova KM, Wilson A, Yu XC, Lombardo VK. Baugh SD, et al. Among authors: gay jp. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3836-9. doi: 10.1016/j.bmcl.2015.07.066. Epub 2015 Jul 26. Bioorg Med Chem Lett. 2015. PMID: 26235947
37 results