Hardcastle IR - Search Results

1

Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes.

Phillips DH, Carmichael PL, Hewer A, Cole KJ, Hardcastle IR, Poon GK, Keogh A, Strain AJ. Phillips DH, et al. Among authors: hardcastle ir. Carcinogenesis. 1996 Jan;17(1):89-94. doi: 10.1093/carcin/17.1.89. Carcinogenesis. 1996. PMID: 8565142

2

Synthesis and DNA reactivity of alpha-hydroxylated metabolites of nonsteroidal antiestrogens.

Hardcastle IR, Horton MN, Osborne MR, Hewer A, Jarman M, Phillips DH. Hardcastle IR, et al. Chem Res Toxicol. 1998 Apr;11(4):369-74. doi: 10.1021/tx970198+. Chem Res Toxicol. 1998. PMID: 9548808

3

4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.

Osborne MR, Davis W, Hewer AJ, Hardcastle IR, Phillips DH. Osborne MR, et al. Among authors: hardcastle ir. Chem Res Toxicol. 1999 Feb;12(2):151-8. doi: 10.1021/tx980187w. Chem Res Toxicol. 1999. PMID: 10027792

4

Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.

Osborne MR, Hewer A, Davis W, Strain AJ, Keogh A, Hardcastle IR, Phillips DH. Osborne MR, et al. Among authors: hardcastle ir. Carcinogenesis. 1999 Feb;20(2):293-7. doi: 10.1093/carcin/20.2.293. Carcinogenesis. 1999. PMID: 10069467

5

Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen.

Osborne MR, Hewer A, Hardcastle IR, Carmichael PL, Phillips DH. Osborne MR, et al. Among authors: hardcastle ir. Cancer Res. 1996 Jan 1;56(1):66-71. Cancer Res. 1996. PMID: 8548777

6

Minor products of reaction of DNA with alpha-acetoxytamoxifen.

Osborne MR, Hardcastle IR, Phillips DH. Osborne MR, et al. Among authors: hardcastle ir. Carcinogenesis. 1997 Mar;18(3):539-43. doi: 10.1093/carcin/18.3.539. Carcinogenesis. 1997. PMID: 9067554

7

An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.

Walton MI, Wilson SC, Hardcastle IR, Mirza AR, Workman P. Walton MI, et al. Among authors: hardcastle ir. Mol Cancer Ther. 2005 Sep;4(9):1369-77. doi: 10.1158/1535-7163.MCT-04-0341. Mol Cancer Ther. 2005. PMID: 16170029

8

Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues.

Rowlands MG, Budworth J, Jarman M, Hardcastle IR, McCague R, Gescher A. Rowlands MG, et al. Among authors: hardcastle ir. Biochem Pharmacol. 1995 Aug 25;50(5):723-6. doi: 10.1016/0006-2952(95)00186-4. Biochem Pharmacol. 1995. PMID: 7669076

9

Rationally designed analogues of tamoxifen with improved calmodulin antagonism.

Hardcastle IR, Rowlands MG, Houghton J, Parr IB, Potter GA, Jarman M, Edwards KJ, Laughton CA, Trent JO, Neidle S. Hardcastle IR, et al. J Med Chem. 1995 Jan 20;38(2):241-8. doi: 10.1021/jm00002a005. J Med Chem. 1995. PMID: 7830266

10

Homologs of idoxifene: variation of estrogen receptor binding and calmodulin antagonism with chain length.

Hardcastle IR, Rowlands MG, Grimshaw RM, Houghton J, Jarman M. Hardcastle IR, et al. J Med Chem. 1996 Feb 16;39(4):999-1004. doi: 10.1021/jm9505472. J Med Chem. 1996. PMID: 8632423

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