Park BK - Search Results

1

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

Maggs JL, Williams D, Pirmohamed M, Park BK. Maggs JL, et al. Among authors: park bk. J Pharmacol Exp Ther. 1995 Dec;275(3):1463-75. J Pharmacol Exp Ther. 1995. PMID: 8531117

2

The role of metabolic activation in drug-induced hepatotoxicity.

Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.

3

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK. Graham EE, et al. Among authors: park bk. J Pharmacol Exp Ther. 2008 Aug;326(2):657-71. doi: 10.1124/jpet.107.135483. Epub 2008 May 1. J Pharmacol Exp Ther. 2008. PMID: 18451316 Free article.

4

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.

Meng X, Jenkins RE, Berry NG, Maggs JL, Farrell J, Lane CS, Stachulski AV, French NS, Naisbitt DJ, Pirmohamed M, Park BK. Meng X, et al. Among authors: park bk. J Pharmacol Exp Ther. 2011 Sep;338(3):841-9. doi: 10.1124/jpet.111.183871. Epub 2011 Jun 16. J Pharmacol Exp Ther. 2011. PMID: 21680886 Free PMC article.

5

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro.

Williams DP, O'Donnell CJ, Maggs JL, Leeder JS, Uetrecht J, Pirmohamed M, Park BK. Williams DP, et al. Among authors: park bk. Chem Res Toxicol. 2003 Oct;16(10):1359-64. doi: 10.1021/tx034035z. Chem Res Toxicol. 2003. PMID: 14565776

6

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro.

Pirmohamed M, Kitteringham NR, Guenthner TM, Breckenridge AM, Park BK. Pirmohamed M, et al. Among authors: park bk. Biochem Pharmacol. 1992 Apr 15;43(8):1675-82. doi: 10.1016/0006-2952(92)90696-g. Biochem Pharmacol. 1992. PMID: 1575766

7

Idiosyncratic reactions to antidepressants: a review of the possible mechanisms and predisposing factors.

Pirmohamed M, Kitteringham NR, Park BK. Pirmohamed M, et al. Among authors: park bk. Pharmacol Ther. 1992;53(1):105-25. doi: 10.1016/0163-7258(92)90046-3. Pharmacol Ther. 1992. PMID: 1641399 Review.

8

An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin.

Riley RJ, Maggs JL, Lambert C, Kitteringham NR, Park BK. Riley RJ, et al. Among authors: park bk. Br J Clin Pharmacol. 1988 Nov;26(5):577-88. doi: 10.1111/j.1365-2125.1988.tb05298.x. Br J Clin Pharmacol. 1988. PMID: 3207562 Free PMC article.

9

A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes.

Kitteringham NR, Lambert C, Maggs JL, Colbert J, Park BK. Kitteringham NR, et al. Among authors: park bk. Br J Clin Pharmacol. 1988 Jul;26(1):13-21. doi: 10.1111/j.1365-2125.1988.tb03358.x. Br J Clin Pharmacol. 1988. PMID: 3264509 Free PMC article.

10

Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man.

Maggs JL, Tingle MD, Kitteringham NR, Park BK. Maggs JL, et al. Among authors: park bk. Biochem Pharmacol. 1988 Jan 15;37(2):303-11. doi: 10.1016/0006-2952(88)90733-2. Biochem Pharmacol. 1988. PMID: 3342086

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