Chern JW - Search Results

1

Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase.

Chern JW, Lee HY, Chen CS, Shewach DS, Daddona PE, Townsend LB. Chern JW, et al. J Med Chem. 1993 Apr 16;36(8):1024-31. doi: 10.1021/jm00060a010. J Med Chem. 1993. PMID: 8478902

2

Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine.

Shewach DS, Chern JW, Pillote KE, Townsend LB, Daddona PE. Shewach DS, et al. Among authors: chern jw. Cancer Res. 1986 Feb;46(2):519-23. Cancer Res. 1986. PMID: 3079664

3

Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors.

Daddona PE, Wiesmann WP, Milhouse W, Chern JW, Townsend LB, Hershfield MS, Webster HK. Daddona PE, et al. Among authors: chern jw. J Biol Chem. 1986 Sep 5;261(25):11667-73. J Biol Chem. 1986. PMID: 3091593 Free article.

4

2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with inbuilt β-N-hydroxy-γ-keto-acid pharmacophore as HCV NS5B polymerase inhibitors.

Deore RR, Chen GS, Chen CS, Chang PT, Chuang MH, Chern TR, Wang HC, Chern JW. Deore RR, et al. Among authors: chern tr, chern jw. Curr Med Chem. 2012;19(4):613-24. doi: 10.2174/092986712798918833. Curr Med Chem. 2012. PMID: 22204334 Review.

5

Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.

Chern JW, Tao PL, Yen MH, Lu GY, Shiau CY, Lai YJ, Chien SL, Chan CH. Chern JW, et al. J Med Chem. 1993 Jul 23;36(15):2196-207. doi: 10.1021/jm00067a017. J Med Chem. 1993. PMID: 8101878

6

Synthesis and cytotoxic evaluation of substituted sulfonyl-N-hydroxyguanidine derivatives as potential antitumor agents.

Chern JW, Leu YL, Wang SS, Jou R, Lee CF, Tsou PC, Hsu SC, Liaw YC, Lin HM. Chern JW, et al. J Med Chem. 1997 Jul 4;40(14):2276-86. doi: 10.1021/jm9607818. J Med Chem. 1997. PMID: 9216847

7

Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).

Leu YL, Roffler SR, Chern JW. Leu YL, et al. Among authors: chern jw. J Med Chem. 1999 Sep 9;42(18):3623-8. doi: 10.1021/jm990124q. J Med Chem. 1999. PMID: 10479293

8

Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.

Chern JW, Tao PL, Wang KC, Gutcait A, Liu SW, Yen MH, Chien SL, Rong JK. Chern JW, et al. J Med Chem. 1998 Aug 13;41(17):3128-41. doi: 10.1021/jm970159v. J Med Chem. 1998. PMID: 9703460

9

NS5B RNA dependent RNA polymerase inhibitors: the promising approach to treat hepatitis C virus infections.

Deore RR, Chern JW. Deore RR, et al. Among authors: chern jw. Curr Med Chem. 2010;17(32):3806-26. doi: 10.2174/092986710793205471. Curr Med Chem. 2010. PMID: 20858218 Review.

10

Unusual conformational flexibility in N1-substituted uncommon purine nucleosides. Crystal structure of 1-allyl-isoguanosine and 1-allyl-xanthosine.

Liaw YC, Chern JW, Lin GS, Wang AH. Liaw YC, et al. Among authors: chern jw. FEBS Lett. 1992 Feb 3;297(1-2):4-8. doi: 10.1016/0014-5793(92)80315-8. FEBS Lett. 1992. PMID: 1551434 Free article.

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