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Page 1
Peptidomimetic inhibitors of the human cytomegalovirus protease.
Ogilvie W, Bailey M, Poupart MA, Abraham A, Bhavsar A, Bonneau P, Bordeleau J, Bousquet Y, Chabot C, Duceppe JS, Fazal G, Goulet S, Grand-Maître C, Guse I, Halmos T, Lavallée P, Leach M, Malenfant E, O'Meara J, Plante R, Plouffe C, Poirier M, Soucy F, Yoakim C, Déziel R. Ogilvie W, et al. J Med Chem. 1997 Dec 5;40(25):4113-35. doi: 10.1021/jm970104t. J Med Chem. 1997. PMID: 9406601
Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
Hucke O, Coulombe R, Bonneau P, Bertrand-Laperle M, Brochu C, Gillard J, Joly MA, Landry S, Lepage O, Llinàs-Brunet M, Pesant M, Poirier M, Poirier M, McKercher G, Marquis M, Kukolj G, Beaulieu PL, Stammers TA. Hucke O, et al. J Med Chem. 2014 Mar 13;57(5):1932-43. doi: 10.1021/jm4004522. Epub 2013 Jul 12. J Med Chem. 2014. PMID: 23773186
Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.
O'Meara JA, Yoakim C, Bonneau PR, Bös M, Cordingley MG, Déziel R, Doyon L, Duan J, Garneau M, Guse I, Landry S, Malenfant E, Naud J, Ogilvie WW, Thavonekham B, Simoneau B. O'Meara JA, et al. Among authors: bonneau pr. J Med Chem. 2005 Aug 25;48(17):5580-8. doi: 10.1021/jm050255t. J Med Chem. 2005. PMID: 16107158
38 results