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203 results

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Page 1
Ionization characteristics of the Cys-25/His-159 interactive system and of the modulatory group of papain: resolution of ambiguity by electronic perturbation of the quasi-2-mercaptopyridine leaving group in a new pyrimidyl disulphide reactivity probe.
Mellor GW, Thomas EW, Topham CM, Brocklehurst K. Mellor GW, et al. Among authors: brocklehurst k. Biochem J. 1993 Feb 15;290 ( Pt 1)(Pt 1):289-96. doi: 10.1042/bj2900289. Biochem J. 1993. PMID: 8439297 Free PMC article.
Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.
Hussain S, Pinitglang S, Bailey TS, Reid JD, Noble MA, Resmini M, Thomas EW, Greaves RB, Verma CS, Brocklehurst K. Hussain S, et al. Among authors: brocklehurst k. Biochem J. 2003 Jun 15;372(Pt 3):735-46. doi: 10.1042/BJ20030177. Biochem J. 2003. PMID: 12643810 Free PMC article.
Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.
Gul S, Sonkaria S, Pinitglang S, Florez-Alvarez J, Hussain S, Thomas EW, Ostler EL, Gallacher G, Resmini M, Brocklehurst K. Gul S, et al. Among authors: brocklehurst k. Biochem J. 2003 Dec 15;376(Pt 3):813-21. doi: 10.1042/BJ20030716. Biochem J. 2003. PMID: 12946271 Free PMC article.
Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain.
Patel M, Kayani IS, Templeton W, Mellor GW, Thomas EW, Brocklehurst K. Patel M, et al. Among authors: brocklehurst k. Biochem J. 1992 Nov 1;287 ( Pt 3)(Pt 3):881-9. doi: 10.1042/bj2870881. Biochem J. 1992. PMID: 1445247 Free PMC article.
The results of a study of the pH-dependence of the second-order rate constant (k) for its reaction with the catalytic-site thiol group (Cys-25) of papain (EC 3.4.22.2) together with analogous kinetic data for the reactions of related time-dependent inhibitors, notably the …
The results of a study of the pH-dependence of the second-order rate constant (k) for its reaction with the catalytic-site thiol grou …
Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.
Topham CM, Salih E, Frazao C, Kowlessur D, Overington JP, Thomas M, Brocklehurst SM, Patel M, Thomas EW, Brocklehurst K. Topham CM, et al. Among authors: brocklehurst sm, brocklehurst k. Biochem J. 1991 Nov 15;280 ( Pt 1)(Pt 1):79-92. doi: 10.1042/bj2800079. Biochem J. 1991. PMID: 1741760 Free PMC article.
A polyclonal antibody preparation with Michaelian catalytic properties.
Gallacher G, Jackson CS, Searcey M, Badman GT, Goel R, Topham CM, Mellor GW, Brocklehurst K. Gallacher G, et al. Among authors: brocklehurst k. Biochem J. 1991 Nov 1;279 ( Pt 3)(Pt 3):871-81. doi: 10.1042/bj2790871. Biochem J. 1991. PMID: 1953683 Free PMC article.
203 results