Vacca JP - Search Results

1

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Vacca JP, Dorsey BD, Schleif WA, Levin RB, McDaniel SL, Darke PL, Zugay J, Quintero JC, Blahy OM, Roth E, et al. Vacca JP, et al. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4096-100. doi: 10.1073/pnas.91.9.4096. Proc Natl Acad Sci U S A. 1994. PMID: 8171040 Free PMC article.

2

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

Darke PL, Kohl NE, Hanobik MG, Leu CT, Vacca JP, Guare JP, Heimbach JC, Dixon RA. Darke PL, et al. Among authors: vacca jp. Adv Exp Med Biol. 1991;306:483-7. doi: 10.1007/978-1-4684-6012-4_61. Adv Exp Med Biol. 1991. PMID: 1812746 No abstract available.

3

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: vacca jp. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

4

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. Vacca JP, et al. J Med Chem. 1991 Mar;34(3):1225-8. doi: 10.1021/jm00107a050. J Med Chem. 1991. PMID: 2002465 No abstract available.

5

Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.

Hungate RW, Chen JL, Starbuck KE, Vacca JP, McDaniel SL, Levin RB, Dorsey BD, Guare JP, Holloway MK, Whitter W, et al. Hungate RW, et al. Among authors: vacca jp. Bioorg Med Chem. 1994 Sep;2(9):859-79. doi: 10.1016/s0968-0896(00)82037-4. Bioorg Med Chem. 1994. PMID: 7712123

6

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

Holloway MK, Wai JM, Halgren TA, Fitzgerald PM, Vacca JP, Dorsey BD, Levin RB, Thompson WJ, Chen LJ, deSolms SJ. Holloway MK, et al. Among authors: vacca jp. J Med Chem. 1995 Jan 20;38(2):305-17. doi: 10.1021/jm00002a012. J Med Chem. 1995. PMID: 7830273

7

Design of tight-binding human immunodeficiency virus type 1 protease inhibitors.

Vacca JP. Vacca JP. Methods Enzymol. 1994;241:311-34. doi: 10.1016/0076-6879(94)41071-2. Methods Enzymol. 1994. PMID: 7854186 Review. No abstract available.

8

L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.

Dorsey BD, Levin RB, McDaniel SL, Vacca JP, Guare JP, Darke PL, Zugay JA, Emini EA, Schleif WA, Quintero JC, et al. Dorsey BD, et al. Among authors: vacca jp. J Med Chem. 1994 Oct 14;37(21):3443-51. doi: 10.1021/jm00047a001. J Med Chem. 1994. PMID: 7932573

9

Synthesis of a series of potent and orally bioavailable thrombin inhibitors that utilize 3,3-disubstituted propionic acid derivatives in the P3 position.

Tucker TJ, Lumma WC, Lewis SD, Gardell SJ, Lucas BJ, Sisko JT, Lynch JJ, Lyle EA, Baskin EP, Woltmann RF, Appleby SD, Chen IW, Dancheck KB, Naylor-Olsen AM, Krueger JA, Cooper CM, Vacca JP. Tucker TJ, et al. Among authors: vacca jp. J Med Chem. 1997 Oct 24;40(22):3687-93. doi: 10.1021/jm970397q. J Med Chem. 1997. PMID: 9357536

10

Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.

Feng DM, Gardell SJ, Lewis SD, Bock MG, Chen Z, Freidinger RM, Naylor-Olsen AM, Ramjit HG, Woltmann R, Baskin EP, Lynch JJ, Lucas R, Shafer JA, Dancheck KB, Chen IW, Mao SS, Krueger JA, Hare TR, Mulichak AM, Vacca JP. Feng DM, et al. Among authors: vacca jp. J Med Chem. 1997 Nov 7;40(23):3726-33. doi: 10.1021/jm970493r. J Med Chem. 1997. PMID: 9371237

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

132 results

Search Page