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Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
Malu S, De Ioannes P, Kozlov M, Greene M, Francis D, Hanna M, Pena J, Escalante CR, Kurosawa A, Erdjument-Bromage H, Tempst P, Adachi N, Vezzoni P, Villa A, Aggarwal AK, Cortes P. Malu S, et al. Among authors: cortes p. J Exp Med. 2012 May 7;209(5):955-63. doi: 10.1084/jem.20111437. Epub 2012 Apr 23. J Exp Med. 2012. PMID: 22529269 Free PMC article.
V(D)J recombination: in vitro coding joint formation.
Weis-Garcia F, Besmer E, Sawchuk DJ, Yu W, Hu Y, Cassard S, Nussenzweig MC, Cortes P. Weis-Garcia F, et al. Among authors: cortes p. Mol Cell Biol. 1997 Nov;17(11):6379-85. doi: 10.1128/MCB.17.11.6379. Mol Cell Biol. 1997. PMID: 9343399 Free PMC article.
Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies.
Gomez CA, Ptaszek LM, Villa A, Bozzi F, Sobacchi C, Brooks EG, Notarangelo LD, Spanopoulou E, Pan ZQ, Vezzoni P, Cortes P, Santagata S. Gomez CA, et al. Among authors: cortes p. Mol Cell Biol. 2000 Aug;20(15):5653-64. doi: 10.1128/MCB.20.15.5653-5664.2000. Mol Cell Biol. 2000. PMID: 10891502 Free PMC article.
355 results