Mutation spectrum of MSH3-deficient HHUA/chr.2 cells reflects in vivo activity of the MSH3 gene product in mismatch repair.
Tauchi H, Komatsu K, Ishizaki K, Yatagai F, Kato T.
Tauchi H, et al. Among authors: kato t.
Mutat Res. 2000 Feb 14;447(2):155-64. doi: 10.1016/s0027-5107(99)00199-2.
Mutat Res. 2000.
PMID: 10751599
Base substitutions and +/-1 bp frameshifts were the major mutational events constituting, respectively, 54% and 42% of the total mutations, and more than 70% of them occurred at A:T sites. A possible explanation for the apparent bias of mutations to A:T sites in HHU …
Base substitutions and +/-1 bp frameshifts were the major mutational events constituting, respectively, 54% and 42% of the total mutations, …