Howe WJ - Search Results

1

The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.

Mildner AM, Rothrock DJ, Leone JW, Bannow CA, Lull JM, Reardon IM, Sarcich JL, Howe WJ, Tomich CS, Smith CW, et al. Mildner AM, et al. Among authors: howe wj. Biochemistry. 1994 Aug 16;33(32):9405-13. doi: 10.1021/bi00198a005. Biochemistry. 1994. PMID: 8068616

2

Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease.

Tomasselli AG, Sarcich JL, Barrett LJ, Reardon IM, Howe WJ, Evans DB, Sharma SK, Heinrikson RL. Tomasselli AG, et al. Among authors: howe wj. Protein Sci. 1993 Dec;2(12):2167-76. doi: 10.1002/pro.5560021216. Protein Sci. 1993. PMID: 7507754 Free PMC article.

3

Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2.

Tomasselli AG, Howe WJ, Hui JO, Sawyer TK, Reardon IM, DeCamp DL, Craik CS, Heinrikson RL. Tomasselli AG, et al. Among authors: howe wj. Proteins. 1991;10(1):1-9. doi: 10.1002/prot.340100102. Proteins. 1991. PMID: 2062825

4

Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2.

Tomasselli AG, Hui JO, Sawyer TK, Staples DJ, Bannow C, Reardon IM, Howe WJ, DeCamp DL, Craik CS, Heinrikson RL. Tomasselli AG, et al. Among authors: howe wj. J Biol Chem. 1990 Aug 25;265(24):14675-83. J Biol Chem. 1990. PMID: 2201691 Free article.

5

CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.

Hoogewerf AJ, Leone JW, Reardon IM, Howe WJ, Asa D, Heinrikson RL, Ledbetter SR. Hoogewerf AJ, et al. Among authors: howe wj. J Biol Chem. 1995 Feb 17;270(7):3268-77. doi: 10.1074/jbc.270.7.3268. J Biol Chem. 1995. PMID: 7852412 Free article.

6

HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs.

Sawyer TK, Staples DJ, Liu L, Tomasselli AG, Hui JO, O'Connell K, Schostarez H, Hester JB, Moon J, Howe WJ, et al. Sawyer TK, et al. Among authors: howe wj. Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):274-81. doi: 10.1111/j.1399-3011.1992.tb00302.x. Int J Pept Protein Res. 1992. PMID: 1478785

7

Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.

Thaisrivongs S, Turner SR, Strohbach JW, TenBrink RE, Tarpley WG, McQuade TJ, Heinrikson RL, Tomasselli AG, Hui JO, Howe WJ. Thaisrivongs S, et al. Among authors: howe wj. J Med Chem. 1993 Apr 16;36(8):941-52. doi: 10.1021/jm00060a001. J Med Chem. 1993. PMID: 8478908

8

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.

Thaisrivongs S, Tomasselli AG, Moon JB, Hui J, McQuade TJ, Turner SR, Strohbach JW, Howe WJ, Tarpley WG, Heinrikson RL. Thaisrivongs S, et al. Among authors: howe wj. J Med Chem. 1991 Aug;34(8):2344-56. doi: 10.1021/jm00112a005. J Med Chem. 1991. PMID: 1875334

9

Use of medium-sized cycloalkyl rings to enhance secondary binding: discovery of a new class of human immunodeficiency virus (HIV) protease inhibitors.

Romines KR, Watenpaugh KD, Tomich PK, Howe WJ, Morris JK, Lovasz KD, Mulichak AM, Finzel BC, Lynn JC, Horng MM, et al. Romines KR, et al. Among authors: howe wj. J Med Chem. 1995 May 26;38(11):1884-91. doi: 10.1021/jm00011a008. J Med Chem. 1995. PMID: 7783120

10

Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.

Thaisrivongs S, Watenpaugh KD, Howe WJ, Tomich PK, Dolak LA, Chong KT, Tomich CC, Tomasselli AG, Turner SR, Strohbach JW, et al. Thaisrivongs S, et al. Among authors: howe wj. J Med Chem. 1995 Sep 1;38(18):3624-37. doi: 10.1021/jm00018a023. J Med Chem. 1995. PMID: 7658450

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

24 results

Search Page

Filters