Wonacott A - Search Results

1

X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease.

Jhoti H, Singh OM, Weir MP, Cooke R, Murray-Rust P, Wonacott A. Jhoti H, et al. Among authors: wonacott a. Biochemistry. 1994 Jul 19;33(28):8417-27. doi: 10.1021/bi00194a005. Biochemistry. 1994. PMID: 8031777

2

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.

Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW. Weir MP, et al. Among authors: wonacott aj. Biochemistry. 1998 May 12;37(19):6645-57. doi: 10.1021/bi972499o. Biochemistry. 1998. PMID: 9578548

3

Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.

Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A. Jhoti H, et al. Among authors: wonacott a. Biochemistry. 1999 Jun 22;38(25):7969-77. doi: 10.1021/bi9830359. Biochemistry. 1999. PMID: 10387040

4

A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.

Wonacott A, Cooke R, Hayes FR, Hann MM, Jhoti H, McMeekin P, Mistry A, Murray-Rust P, Singh OM, Weir MP. Wonacott A, et al. J Med Chem. 1993 Oct 15;36(21):3113-9. doi: 10.1021/jm00073a010. J Med Chem. 1993. PMID: 8230097

5

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J. Taylor NR, et al. Among authors: wonacott aj. J Med Chem. 1998 Mar 12;41(6):798-807. doi: 10.1021/jm9703754. J Med Chem. 1998. PMID: 9526556

6

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.

Tsai FT, Singh OM, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB. Tsai FT, et al. Among authors: wonacott aj. Proteins. 1997 May;28(1):41-52. Proteins. 1997. PMID: 9144789

7

X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity.

Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, Hood AM, Modi S, Hersey A, Taskinen J, Cooke RM, Manchee GR, Coughtrie MW. Dajani R, et al. Among authors: wonacott aj. J Biol Chem. 1999 Dec 31;274(53):37862-8. doi: 10.1074/jbc.274.53.37862. J Biol Chem. 1999. PMID: 10608851 Free article.

8

Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein.

Lewis RJ, Singh OM, Smith CV, Maxwell A, Skarzynski T, Wonacott AJ, Wigley DB. Lewis RJ, et al. Among authors: wonacott aj. J Mol Biol. 1994 Aug 5;241(1):128-30. doi: 10.1006/jmbi.1994.1480. J Mol Biol. 1994. PMID: 8051702

9

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography.

Lewis RJ, Singh OM, Smith CV, Skarzynski T, Maxwell A, Wonacott AJ, Wigley DB. Lewis RJ, et al. Among authors: wonacott aj. EMBO J. 1996 Mar 15;15(6):1412-20. EMBO J. 1996. PMID: 8635474 Free PMC article.

10

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Slater MJ, et al. Among authors: wonacott a. J Med Chem. 2007 Mar 8;50(5):897-900. doi: 10.1021/jm061207r. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269759

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