Cygler M - Search Results

1

Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.

Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y. Tsuda Y, et al. Among authors: cygler m. Biochemistry. 1994 Dec 6;33(48):14443-51. doi: 10.1021/bi00252a010. Biochemistry. 1994. PMID: 7981204

2

Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.

Rehse PH, Steinmetzer T, Li Y, Konishi Y, Cygler M. Rehse PH, et al. Among authors: cygler m. Biochemistry. 1995 Sep 12;34(36):11537-44. doi: 10.1021/bi00036a029. Biochemistry. 1995. PMID: 7547884

3

Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin.

Szewczuk Z, Gibbs BF, Yue SY, Purisima E, Zdanov A, Cygler M, Konishi Y. Szewczuk Z, et al. Among authors: cygler m. Biochemistry. 1993 Apr 6;32(13):3396-404. doi: 10.1021/bi00064a025. Biochemistry. 1993. PMID: 8461303

4

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.

Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M. Féthière J, et al. Among authors: cygler m. Protein Sci. 1996 Jun;5(6):1174-83. doi: 10.1002/pro.5560050620. Protein Sci. 1996. PMID: 8762149 Free PMC article.

5

Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.

Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y. Slon-Usakiewicz JJ, et al. Among authors: cygler m. Biochemistry. 1997 Nov 4;36(44):13494-502. doi: 10.1021/bi970857h. Biochemistry. 1997. PMID: 9354617

6

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.

Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y. Slon-Usakiewicz JJ, et al. Among authors: cygler m. Biochemistry. 2000 Mar 7;39(9):2384-91. Biochemistry. 2000. PMID: 10694407

7

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.

Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M. Zdanov A, et al. Among authors: cygler m. Proteins. 1993 Nov;17(3):252-65. doi: 10.1002/prot.340170304. Proteins. 1993. PMID: 8272424

8

Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes.

Féthière J, Eggimann B, Cygler M. Féthière J, et al. Among authors: cygler m. J Mol Biol. 1999 May 14;288(4):635-47. doi: 10.1006/jmbi.1999.2698. J Mol Biol. 1999. PMID: 10329169

9

Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides.

Chowdhury SF, Sivaraman J, Wang J, Devanathan G, Lachance P, Qi H, Ménard R, Lefebvre J, Konishi Y, Cygler M, Sulea T, Purisima EO. Chowdhury SF, et al. Among authors: cygler m. J Med Chem. 2002 Nov 21;45(24):5321-9. doi: 10.1021/jm020238t. J Med Chem. 2002. PMID: 12431059

10

Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase.

Grochulski P, Bouthillier F, Kazlauskas RJ, Serreqi AN, Schrag JD, Ziomek E, Cygler M. Grochulski P, et al. Among authors: cygler m. Biochemistry. 1994 Mar 29;33(12):3494-500. doi: 10.1021/bi00178a005. Biochemistry. 1994. PMID: 8142346

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