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8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
Ciardiello F, Tortora G, Kim N, Clair T, Ally S, Salomon DS, Cho-Chung YS. Ciardiello F, et al. J Biol Chem. 1990 Jan 15;265(2):1016-20. J Biol Chem. 1990. PMID: 1688548 Free article.
Such selective modulation of protein kinase isozyme regulatory subunits was also found in the 8-Cl-cAMP-induced inhibition of both transformation and transforming growth factor alpha (TGF alpha) production in Ki-ras-transformed rat kidney fibroblasts (Tortora, G., Ciardiello …
Such selective modulation of protein kinase isozyme regulatory subunits was also found in the 8-Cl-cAMP-induced inhibition of both transform …
639 results