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Serum antibodies from malaria-exposed people recognize conserved epitopes formed by the two epidermal growth factor motifs of MSP1(19), the carboxy-terminal fragment of the major merozoite surface protein of Plasmodium falciparum.
Egan AF, Chappel JA, Burghaus PA, Morris JS, McBride JS, Holder AA, Kaslow DC, Riley EM. Egan AF, et al. Infect Immun. 1995 Feb;63(2):456-66. doi: 10.1128/iai.63.2.456-466.1995. Infect Immun. 1995. PMID: 7822010 Free PMC article.
Immunization of Aotus nancymai with recombinant C terminus of Plasmodium falciparum merozoite surface protein 1 in liposomes and alum adjuvant does not induce protection against a challenge infection.
Burghaus PA, Wellde BT, Hall T, Richards RL, Egan AF, Riley EM, Ballou WR, Holder AA. Burghaus PA, et al. Among authors: egan af. Infect Immun. 1996 Sep;64(9):3614-9. doi: 10.1128/iai.64.9.3614-3619.1996. Infect Immun. 1996. PMID: 8751907 Free PMC article.
Phase I trial of two recombinant vaccines containing the 19kd carboxy terminal fragment of Plasmodium falciparum merozoite surface protein 1 (msp-1(19)) and T helper epitopes of tetanus toxoid.
Keitel WA, Kester KE, Atmar RL, White AC, Bond NH, Holland CA, Krzych U, Palmer DR, Egan A, Diggs C, Ballou WR, Hall BF, Kaslow D. Keitel WA, et al. Vaccine. 1999 Oct 14;18(5-6):531-9. doi: 10.1016/s0264-410x(99)00221-2. Vaccine. 1999. PMID: 10519944 Clinical Trial.
39 results