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Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine.
Pushkareva M, Chao R, Bielawska A, Merrill AH Jr, Crane HM, Lagu B, Liotta D, Hannun YA. Pushkareva M, et al. Among authors: chao r. Biochemistry. 1995 Feb 14;34(6):1885-92. doi: 10.1021/bi00006a009. Biochemistry. 1995. PMID: 7849048
More recently, D-erythro-sphingosine has been shown to act as an early inducer of dephosphorylation of the retinoblastoma gene product (pRb) in the lymphoblastic leukemia cell line MOLT-4 [Chao, R., Khan, W., & Hannun, Y.A. (1992) J. Biol. Chem., 267, 23459-2346 …
More recently, D-erythro-sphingosine has been shown to act as an early inducer of dephosphorylation of the retinoblastoma gene product (pRb) …
Sitravatinib in patients with solid tumors selected by molecular alterations: results from a Phase Ib study.
Bazhenova L, Kim DW, Cho BC, Goel S, Heist R, Werner TL, Eaton KD, Wang JS, Pant S, Adkins DR, Blakely CM, Yan X, Neuteboom S, Christensen JG, Chao R, Bauer T. Bazhenova L, et al. Among authors: chao r. Future Oncol. 2024 Dec;20(39):3213-3227. doi: 10.1080/14796694.2024.2418285. Epub 2024 Nov 8. Future Oncol. 2024. PMID: 39513224 Free PMC article. Clinical Trial.
260 results