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The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M, Mandelkow E. Biernat J, et al. Among authors: lichtenberg kraag b. EMBO J. 1992 Apr;11(4):1593-7. doi: 10.1002/j.1460-2075.1992.tb05204.x. EMBO J. 1992. PMID: 1563356 Free PMC article.
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