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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. Hruby VJ, et al. Among authors: castrucci al. J Med Chem. 1995 Sep 1;38(18):3454-61. doi: 10.1021/jm00018a005. J Med Chem. 1995. PMID: 7658432