Beigelman L - Search Results

1

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance.

Beigelman L, McSwiggen JA, Draper KG, Gonzalez C, Jensen K, Karpeisky AM, Modak AS, Matulic-Adamic J, DiRenzo AB, Haeberli P, et al. Beigelman L, et al. J Biol Chem. 1995 Oct 27;270(43):25702-8. doi: 10.1074/jbc.270.43.25702. J Biol Chem. 1995. PMID: 7592749 Free article.

2

Synthesis of 2'-modified nucleotides and their incorporation into hammerhead ribozymes.

Beigelman L, Karpeisky A, Matulic-Adamic J, Haeberli P, Sweedler D, Usman N. Beigelman L, et al. Nucleic Acids Res. 1995 Nov 11;23(21):4434-42. doi: 10.1093/nar/23.21.4434. Nucleic Acids Res. 1995. PMID: 7501467 Free PMC article.

3

Hammerhead ribozyme engineering.

Usman N, Beigelman L, McSwiggen JA. Usman N, et al. Among authors: beigelman l. Curr Opin Struct Biol. 1996 Aug;6(4):527-33. doi: 10.1016/s0959-440x(96)80119-9. Curr Opin Struct Biol. 1996. PMID: 8794164 Review.

4

Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb.

Jarvis TC, Wincott FE, Alby LJ, McSwiggen JA, Beigelman L, Gustofson J, DiRenzo A, Levy K, Arthur M, Matulic-Adamic J, Karpeisky A, Gonzalez C, Woolf TM, Usman N, Stinchcomb DT. Jarvis TC, et al. Among authors: beigelman l. J Biol Chem. 1996 Nov 15;271(46):29107-12. doi: 10.1074/jbc.271.46.29107. J Biol Chem. 1996. PMID: 8910566 Free article.

5

Chemically modified hammerhead ribozymes with improved catalytic rates.

Burgin AB Jr, Gonzalez C, Matulic-Adamic J, Karpeisky AM, Usman N, McSwiggen JA, Beigelman L. Burgin AB Jr, et al. Among authors: beigelman l. Biochemistry. 1996 Nov 12;35(45):14090-7. doi: 10.1021/bi961264u. Biochemistry. 1996. PMID: 8916894

6

Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state.

Baidya N, Ammons GE, Matulic-Adamic J, Karpeisky AM, Beigelman L, Uhlenbeck OC. Baidya N, et al. Among authors: beigelman l. RNA. 1997 Oct;3(10):1135-42. RNA. 1997. PMID: 9326488 Free PMC article.

7

Nuclease resistant hammerhead motif: from '5-ribo' to '3-ribo' model.

Matulic-Adamic J, Daniher AT, Gonzalez C, Beigelman L. Matulic-Adamic J, et al. Among authors: beigelman l. Bioorg Med Chem Lett. 1999 Jan 18;9(2):157-60. doi: 10.1016/s0960-894x(98)00706-9. Bioorg Med Chem Lett. 1999. PMID: 10021919

8

Synthesis of N-acetyl-D-galactosamine and folic acid conjugated ribozymes.

Matulic-Adamic J, Serebryany V, Haeberli P, Mokler VR, Beigelman L. Matulic-Adamic J, et al. Among authors: beigelman l. Bioconjug Chem. 2002 Sep-Oct;13(5):1071-8. doi: 10.1021/bc025525q. Bioconjug Chem. 2002. PMID: 12236789

9

Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.

Beigelman L, Matulic-Adamic J, Haeberli P, Usman N, Dong B, Silverman RH, Khamnei S, Torrence PF. Beigelman L, et al. Nucleic Acids Res. 1995 Oct 11;23(19):3989-94. doi: 10.1093/nar/23.19.3989. Nucleic Acids Res. 1995. PMID: 7479047 Free PMC article.

10

Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA.

Jarvis TC, Alby LJ, Beaudry AA, Wincott FE, Beigelman L, McSwiggen JA, Usman N, Stinchcomb DT. Jarvis TC, et al. Among authors: beigelman l. RNA. 1996 May;2(5):419-28. RNA. 1996. PMID: 8665409 Free PMC article.

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