Rosenfeld M - Search Results

1

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung.

Crystal RG, Jaffe A, Brody S, Mastrangeli A, McElvaney NG, Rosenfeld M, Chu CS, Danel C, Hay J, Eissa T. Crystal RG, et al. Among authors: rosenfeld m. Hum Gene Ther. 1995 May;6(5):643-66. doi: 10.1089/hum.1995.6.5-643. Hum Gene Ther. 1995. PMID: 7578401 No abstract available.

2

Gene transfer to freshly isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA.

Rosenfeld MA, Chu CS, Seth P, Danel C, Banks T, Yoneyama K, Yoshimura K, Crystal RG. Rosenfeld MA, et al. Hum Gene Ther. 1994 Mar;5(3):331-42. doi: 10.1089/hum.1994.5.3-331. Hum Gene Ther. 1994. PMID: 7517189

3

Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.

Brody SL, Metzger M, Danel C, Rosenfeld MA, Crystal RG. Brody SL, et al. Among authors: rosenfeld ma. Hum Gene Ther. 1994 Jul;5(7):821-36. doi: 10.1089/hum.1994.5.7-821. Hum Gene Ther. 1994. PMID: 7526901

4

Increasing expression of the normal human CFTR cDNA in cystic fibrosis epithelial cells results in a progressive increase in the level of CFTR protein expression, but a limit on the level of cAMP-stimulated chloride secretion.

Rosenfeld MA, Rosenfeld SJ, Danel C, Banks TC, Crystal RG. Rosenfeld MA, et al. Among authors: rosenfeld sj. Hum Gene Ther. 1994 Sep;5(9):1121-9. doi: 10.1089/hum.1994.5.9-1121. Hum Gene Ther. 1994. PMID: 7530494

5

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.

Crystal RG, McElvaney NG, Rosenfeld MA, Chu CS, Mastrangeli A, Hay JG, Brody SL, Jaffe HA, Eissa NT, Danel C. Crystal RG, et al. Among authors: rosenfeld ma. Nat Genet. 1994 Sep;8(1):42-51. doi: 10.1038/ng0994-42. Nat Genet. 1994. PMID: 7527271 Clinical Trial.

6

Gene therapy for the respiratory manifestations of cystic fibrosis.

Korst RJ, McElvaney NG, Chu CS, Rosenfeld MA, Mastrangeli A, Hay J, Brody SL, Eissa NT, Danel C, Jaffe HA, et al. Korst RJ, et al. Among authors: rosenfeld ma. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 2):S75-87. doi: 10.1164/ajrccm/151.3_Pt_2.S75. Am J Respir Crit Care Med. 1995. PMID: 7533609 Review.

7

Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA.

Seth P, Rosenfeld M, Higginbotham J, Crystal RG. Seth P, et al. Among authors: rosenfeld m. J Virol. 1994 Feb;68(2):933-40. doi: 10.1128/JVI.68.2.933-940.1994. J Virol. 1994. PMID: 7507187 Free PMC article.

Given the knowledge that replication-deficient adenoviruses can mediate the delivery of unlinked plasmid DNA into eukaryotic cells (K. Yoshimura, M. A. Rosenfeld, P. Seth, and R. G. Crystal, J. Biol. Chem. 268:2300-2303, 1993), this study focuses on the role of rece …

Given the knowledge that replication-deficient adenoviruses can mediate the delivery of unlinked plasmid DNA into eukaryotic cells (K. Yoshi …

8

Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer.

Yoshimura K, Rosenfeld MA, Nakamura H, Scherer EM, Pavirani A, Lecocq JP, Crystal RG. Yoshimura K, et al. Among authors: rosenfeld ma. Nucleic Acids Res. 1992 Jun 25;20(12):3233-40. doi: 10.1093/nar/20.12.3233. Nucleic Acids Res. 1992. PMID: 1377820 Free PMC article.

9

Gene therapy for pulmonary diseases.

Rosenfeld MA, Ronald G, Crystal RG. Rosenfeld MA, et al. Pathol Biol (Paris). 1993 Oct;41(8):677-80. Pathol Biol (Paris). 1993. PMID: 8290311 Review.

10

Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.

Mastrangeli A, Danel C, Rosenfeld MA, Stratford-Perricaudet L, Perricaudet M, Pavirani A, Lecocq JP, Crystal RG. Mastrangeli A, et al. Among authors: rosenfeld ma. J Clin Invest. 1993 Jan;91(1):225-34. doi: 10.1172/JCI116175. J Clin Invest. 1993. PMID: 8423221 Free PMC article.

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