Luke RW - Search Results

1

Purification and characterization of endogenous peptides extracted from HLA-DR isolated from the spleen of a patient with rheumatoid arthritis.

Gordon RD, Young JA, Rayner S, Luke RW, Crowther ML, Wordsworth P, Bell J, Hassall G, Evans J, Hinchliffe SA, et al. Gordon RD, et al. Among authors: luke rw. Eur J Immunol. 1995 May;25(5):1473-6. doi: 10.1002/eji.1830250553. Eur J Immunol. 1995. PMID: 7539763

2

Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.

Breeze AL, Kara BV, Barratt DG, Anderson M, Smith JC, Luke RW, Best JR, Cartlidge SA. Breeze AL, et al. Among authors: luke rw. EMBO J. 1996 Jul 15;15(14):3579-89. EMBO J. 1996. PMID: 8670861 Free PMC article.

3

Purification of protein tyrosine phosphatase activity from skeletal muscle using a non-hydrolysable phosphopeptide affinity column.

Smith GJ, Foster HR, Orme JP, Holloway BR, Whittamore PR, Luke RW, Cotton R, Abbott WM. Smith GJ, et al. Among authors: luke rw. Biochem Soc Trans. 1997 Nov;25(4):S620. doi: 10.1042/bst025s620. Biochem Soc Trans. 1997. PMID: 9450048 No abstract available.

4

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.

Norman RA, Barry ST, Bate M, Breed J, Colls JG, Ernill RJ, Luke RW, Minshull CA, McAlister MS, McCall EJ, McMiken HH, Paterson DS, Timms D, Tucker JA, Pauptit RA. Norman RA, et al. Among authors: luke rw. Structure. 2004 Jan;12(1):75-84. doi: 10.1016/j.str.2003.11.018. Structure. 2004. PMID: 14725767 Free article.

5

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S. Reigan P, et al. Among authors: luke rw. J Med Chem. 2005 Jan 27;48(2):392-402. doi: 10.1021/jm049494r. J Med Chem. 2005. PMID: 15658853

6

Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.

Luke RW, Ballard P, Buttar D, Campbell L, Curwen J, Emery SC, Griffen AM, Hassall L, Hayter BR, Jones CD, McCoull W, Mellor M, Swain ML, Tucker JA. Luke RW, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6670-4. doi: 10.1016/j.bmcl.2009.10.001. Epub 2009 Oct 13. Bioorg Med Chem Lett. 2009. PMID: 19854647

7

Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.

Buttar D, Edge M, Emery SC, Fitzek M, Forder C, Griffen A, Hayter B, Hayward CF, Hopcroft PJ, Luke RW, Page K, Stawpert J, Wright A. Buttar D, et al. Among authors: luke rw. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4723-6. doi: 10.1016/j.bmcl.2008.06.106. Epub 2008 Jul 23. Bioorg Med Chem Lett. 2008. PMID: 18676144

8

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.

Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RW, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L. Addie M, et al. Among authors: luke rw. J Med Chem. 2013 Mar 14;56(5):2059-73. doi: 10.1021/jm301762v. Epub 2013 Feb 26. J Med Chem. 2013. PMID: 23394218

9

Synthesis of cytidine ribonucleotides by stepwise assembly of the heterocycle on a sugar phosphate.

Ingar AA, Luke RW, Hayter BR, Sutherland JD. Ingar AA, et al. Among authors: luke rw. Chembiochem. 2003 Jun 6;4(6):504-7. doi: 10.1002/cbic.200300554. Chembiochem. 2003. PMID: 12794860

10

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background.

Davies BR, Greenwood H, Dudley P, Crafter C, Yu DH, Zhang J, Li J, Gao B, Ji Q, Maynard J, Ricketts SA, Cross D, Cosulich S, Chresta CC, Page K, Yates J, Lane C, Watson R, Luke R, Ogilvie D, Pass M. Davies BR, et al. Mol Cancer Ther. 2012 Apr;11(4):873-87. doi: 10.1158/1535-7163.MCT-11-0824-T. Epub 2012 Jan 31. Mol Cancer Ther. 2012. PMID: 22294718 Clinical Trial.

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