Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding.
Hammacher A, Ward LD, Weinstock J, Treutlein H, Yasukawa K, Simpson RJ.
Hammacher A, et al. Among authors: ward ld.
Protein Sci. 1994 Dec;3(12):2280-93. doi: 10.1002/pro.5560031213.
Protein Sci. 1994.
PMID: 7538847
Free PMC article.
Previously, we demonstrated that the 5 C-terminal residues of mIL-6 are important for activity, conformation, and stability (Ward LD et al., 1993, Protein Sci 2:1472-1481). To further probe the structure-function relationship of this cytokine, we have constructed se …
Previously, we demonstrated that the 5 C-terminal residues of mIL-6 are important for activity, conformation, and stability (Ward …