Blumberg PM - Search Results

1

Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity.

Kazanietz MG, Lewin NE, Bruns JD, Blumberg PM. Kazanietz MG, et al. Among authors: blumberg pm. J Biol Chem. 1995 May 5;270(18):10777-83. doi: 10.1074/jbc.270.18.10777. J Biol Chem. 1995. PMID: 7537738 Free article.

2

[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins.

Lewin NE, Blumberg PM. Lewin NE, et al. Among authors: blumberg pm. Methods Mol Biol. 2003;233:129-56. doi: 10.1385/1-59259-397-6:129. Methods Mol Biol. 2003. PMID: 12840504 No abstract available.

3

A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.

Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE. Pu Y, et al. Among authors: blumberg pm. J Biol Chem. 2005 Jul 22;280(29):27329-38. doi: 10.1074/jbc.M414132200. Epub 2005 May 27. J Biol Chem. 2005. PMID: 15923197 Free article.

4

Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.

Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM. Choi SH, et al. Among authors: blumberg pm. J Biol Chem. 2008 Apr 18;283(16):10543-9. doi: 10.1074/jbc.M707463200. Epub 2008 Feb 7. J Biol Chem. 2008. PMID: 18263588 Free PMC article.

5

Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.

Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM. Geczy T, et al. Among authors: blumberg pm. J Biol Chem. 2012 Apr 13;287(16):13137-58. doi: 10.1074/jbc.M111.320010. Epub 2012 Feb 18. J Biol Chem. 2012. PMID: 22351766 Free PMC article.

6

Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.

Czikora A, Lundberg DJ, Abramovitz A, Lewin NE, Kedei N, Peach ML, Zhou X, Merritt RC Jr, Craft EA, Braun DC, Blumberg PM. Czikora A, et al. Among authors: blumberg pm. J Biol Chem. 2016 May 20;291(21):11133-47. doi: 10.1074/jbc.M116.725333. Epub 2016 Mar 28. J Biol Chem. 2016. PMID: 27022025 Free PMC article.

7

Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes.

Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG. Cooke M, et al. Among authors: blumberg pm. J Biol Chem. 2018 Jun 1;293(22):8330-8341. doi: 10.1074/jbc.RA117.000235. Epub 2018 Apr 10. J Biol Chem. 2018. PMID: 29636415 Free PMC article.

8

Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.

Wang S, Kazanietz MG, Blumberg PM, Marquez VE, Milne GW. Wang S, et al. Among authors: blumberg pm. J Med Chem. 1996 Jun 21;39(13):2541-53. doi: 10.1021/jm950403n. J Med Chem. 1996. PMID: 8691452

9

Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters.

Caloca MJ, Fernandez N, Lewin NE, Ching D, Modali R, Blumberg PM, Kazanietz MG. Caloca MJ, et al. Among authors: blumberg pm. J Biol Chem. 1997 Oct 17;272(42):26488-96. doi: 10.1074/jbc.272.42.26488. J Biol Chem. 1997. PMID: 9334226 Free article.

10

Binding of [3H]bryostatin 4 to protein kinase C.

Lewin NE, Dell'Aquila ML, Pettit GR, Blumberg PM, Warren BS. Lewin NE, et al. Among authors: blumberg pm. Biochem Pharmacol. 1992 May 8;43(9):2007-14. doi: 10.1016/0006-2952(92)90644-x. Biochem Pharmacol. 1992. PMID: 1596288

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