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Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.
Harlan DM, Hengartner H, Huang ML, Kang YH, Abe R, Moreadith RW, Pircher H, Gray GS, Ohashi PS, Freeman GJ, et al. Harlan DM, et al. Among authors: gray gs. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3137-41. doi: 10.1073/pnas.91.8.3137. Proc Natl Acad Sci U S A. 1994. PMID: 7512724 Free PMC article.
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